Chronic Lymphocytic Anemia Cases--Nikcevich

Question 1

CD5+, CD19+, CD20+, CD23+

flow cytometry

Answer 1

CLL

Question 2

CD5+, CD23-, cyclin D1 +

flow cytometry

Answer 2

mantle cell lymphoma

Question 3

CD38 +

vs

CD38 -

prognosis

Answer 3

CD38 -

–> better prognosis

Question 4

13q-

mutation in CLL

Answer 4

creates fragile cytoskeletons

“smudge cells” seen on slides

indicates good prognosis

Question 5

Mutated Ig V_H indicates…

Answer 5

more mature B-cells

better prognosis

Question 6

17p-

Answer 6

Richter’s transformation

–> poor prognostic sign

–> causes BM failure

–> can occur anytime in course of CLL

Question 7

How does autoimmune hemolytic anemia sequele of CLL correspond to CLL recurrence?

Answer 7

it doesn’t

AHA may occur anytime after CLL, esp when it is remission

Question 8

Ibrutinib

Answer 8

B-cell tyrosine kinase receptor antagonist

used to treat pure red cell aplasia 2˚ to CLL

Question 9

Pure red cell aplasia 2˚ to ALL Tx

Answer 9

ibrutinib

Question 10

Why can you get a hoarse voice from leukemias/lymphomas?

Answer 10

lymphadenopathy of thoracic nodes can impinge the recurrent laryngeal nerve