CLL--Krafts Flashcards

1
Q

BM transplants in lymphoproliferative disease

A

not an option malignancy remains in lymph nodes

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2
Q

CLL odd immunophenotype

A

B-cell, but CD5+

(usually in T-cells and immature B-cells)

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3
Q

CLL cells

A

small, mature lymphocytes

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4
Q

CLL prognostic tool

A

BM section

(diffuse involvement –> worse)

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5
Q

Immunophenotype of CLL

A

+ B-cell antigens

+ CD5

  • TdT
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6
Q

2 lab findings in CLL

A

high WBC

hypogammaglobulinemia

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7
Q

Gene rearrangement of CLL

(commonly)

A

bcl-2

(normally prevents apoptosis–cells become “immortal”)

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8
Q

Hairy Cell Leukemia

physical exam finding

A

splenomegaly without lymphadenopathy

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9
Q

Hair Cell Leukemia

Blood Findings

A

pancytopenia

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10
Q

Hair Cell Leukemia

Stain

A

TRAP +

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11
Q

Hairy Cell Leukemia

men or women?

A

5: 1
men: women

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12
Q
A

Hairy cell leukemia

TRAP stain

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13
Q

Why don’t you get hairy cells out in peripheral blood in hair cell leukemia?

A

hairy cells make reticular fibers around themselves in the BM

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14
Q

Why do you get a pancytopenia in Hair Cell Leukemia?

A

reticular fibers made around hairy cells, makes it harder to get out of marrow

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15
Q

Immunophenotype for hairy cell leukemia

A

+ CD25, CD11c

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16
Q

Always peripheral blood finding in hairy cell leukemia

A

monocytopenia

17
Q

Prolymphotyic Leukemia

physical exam findings

A

splenomegaly without lymphadenopathy

18
Q

Special about prolymphocytic leukemia

A

aggressive

splenomegaly without lymphadenopathy

nucleoli present

19
Q

Large Granulated Lymphocyte Leukemia

Cells

A

T-cell proliferation with neutropenia

20
Q
A

prolymphocytic leukemia

look at the nucleolus!