Non-Hodgkin Lymphomas--Krafts Flashcards
Most common causes of lymphadenopathy
benign
malignant
benign infection reaction
malignant carinomas (not primary blood)
Follicular hyperplasia basics
B-cell proliferation
most often due to infection
tingible body macrophages
What type of cells are in lymph node follicles?
B-cells
What type of cells are found in the interfollicular space?
T-cells
Expanded areas between follicles
interfollicular hyperplasia
Effacement
what is left of follicle in node during interfollicular hyperplasia
benign: some left
malignant: none left
What differentiates NHL and NL for the Sx?
NHL skips around lymph nodes
NL stays in one area of lymph node
NHL cell type
B-cell
almost always
B-symptoms
fever, night sweats, weight loss
staging differentiation
do worse
What are the two subtypes of NHL?
low-grade
high-grade
Small Lymphocytic Lymphoma
same as…
chronic lymphocytic leukemia
B-cell, CD5+
Malt lymphoma
marginal zone lymphoma
dependent on H. pylori (esp. early)
can show up in GI mucosa
This type of lymphoma creates marginal zones in nodes
marginal zone lymphoma
Where do you find malt lymphomas?
mucosal surfaces
mucosa associated lymphoid tissue
ex: GI tract
Mantle Cell Lymphoma
translocation
t(11;14)
bcl-1 and IgH (heavy chain)
*14 has heavy chain genes–if you put something next to this then it will be expressed all the time*
–> disease
*light chains are on 2 and 22*
t(14;18)
Butt cells
follicular lymphoma
Sézary syndrome
cerebriform lymphocytes
Mycosis Fungoides/Sézary Syndrome
Burkitt lymphoma
