Management of Chronic Pain Flashcards
define allodynia
pain from a stimulus that is not normally painful
define hyperalgesia
more pain than expected from a painful stimulus
causes of neuropathic pain
shingles (post herpetic neuralgia) surgery trauma diabetic neuropathy amputation
amitryptilline is a/an…
antidepressant
gabapentin is a/an…
anticonvulsant
what kind of drug is paracetamol?
aniline derivative
main MoA of paracetamol
inhibition of central prostaglandin synthesis
what types of pain are opioids good for?
neuropathic, nociceptive pain
what do opioids do?
activate the endogenous analgesic system
reduce descending and ascending pain signal
side effects of opioids
N+V constipation dizziness/vertigo sleepiness dry skin itch
in what problems are antidepressants good for pain?
neuropathic pain
CRPS
tension headache
MoA of antidepressants?
5-HT inhibitor
side effects of antidepressants
constipation dry mouth sleepiness heart rate/rhythm abnormalities insomnia increased appetite
main target of inhibition by anticonvulsants?
Ca channels
side effects of anticonvulsants?
sedation dizziness ataxia peripheral oedema nausea weight gain
