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NAPLEX > Cancer > Flashcards

Cancer Flashcards

1
Q

Prevalent toxicities BCDMN

IP

VT

BMS

A
  • Bleomycin, busulfan, carmustine, lomustine
  • Cisplatin, carboplatin: nephro/ototox
  • Doxorubicin and other anthracyclines: cardiotoxic
  • MTX: Mucositis
  • Nitrosoureas (lomustine, carmustine: hemorragic cystitis
  • Vinc and taxanes: peripheral neuropathy
  • Bone marrow suppression (BMS)
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2
Q

What are the age ranges for breast cancer screenings?

A

40-44

45-54

>=55

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3
Q

Diarrhea 3 drugs

A

Fluorouracil, capecitabine, irinotecan

I Flu to CAPE cod and RAN TO THE CAN

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4
Q

Mucositis

4 main meds and this class that ends in what?

A

Fluorouracil

capecitabine

irinotecan

MTX

TKIs end in nib

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5
Q

Neuropathy

3 classes

3 drugs

2

3

A

Vinca alkaloids, Vinecristine, vinblastine, vinorelbine

Platinums: cisplatin, oxaliplatin

taxanes: Paclitaxel, docetaxel, cabazitaxel

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6
Q

When should a 43 yo female get a mammogram?

A

Annual mammograms are optional

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7
Q

Nausea and Vomiting

What 3 drugs cause N/V the most?

A

Cyclophosphamide, cisplatin. ifosfamide

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8
Q

Thromboembolic risk

A

SERMS and aromatase inhibitors (anastrozole, letrozole)

SERMS: Tamoxifen

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9
Q

Lung cancer age range for screening?

A

55-74

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10
Q

Myelosuppression

Most chemo drugs do but what three dont?

A

Almost all expect Bleomycin, aspariginase, and vinctristine

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11
Q

Hemorragic cystitis

2 drugs and specific dosing

A

Ifosfamide: all doses

Cyclophosphamide: hgiher doses> 1 gram/m2V

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12
Q

When should a 47 yo get a mammogram?

A

Begin yearly mammograms

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13
Q

WHen should a 57 yo F get mammograms?

A

q 2 years or continue annually

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14
Q

Cardio toxicities

2 categories

1 in one cat

2 in the other

A

Anthracyclines cardiomyopathy

arsenic trioxide, TKIs ending in nib: QT prolongation

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15
Q

Constipation

A

Vinecristine

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16
Q

What is the criteria for getting a annual CT scan of the chest?

A
  • In good health
  • Have at least a 30 pack-year smoking history
  • Still smoking or quit smoking within the past 15 years
17
Q

Hepatotoxicity

Specific class and 3 within

A

Antiandrorgens (bocalutamide, flutamide, nilutamide)

18
Q

Lifetime cumulative dose is 450-550 mg/m2 what is the drug and the reason?

A

Doxorubicin reason is cardiotoxicity

19
Q

Single dose is capped at 2 mg what is the drug and the reason?

A

Vincristine and Neuropathy

20
Q

Nephrotoxicity 2

A

Cisplatin, and MTX

21
Q

When should a 47 year old pt get a colonoscopy?

Multi targeted DNA stool test?

A

Every 10 years

Stool every 3 years

Fecal occult blood test every year

Flexible sigmoidalscopy every 5 years

22
Q

Dose per cycle is not to exceed 100 mg/m2

A

Cisplatin and nephrotox

23
Q

Pulmonary toxicities

4

A

Bleomycin, busulfan, carmustine, lamustine

24
Q

Lifetime cumulative dose is 400 units what is the reason and drug?

A

Bleomycin reason is pulmonary toxicity

25
Q

What four chemo drugs commonly cause pulmonary fibrosis?

A

Bleomycin, Busulfran, Carmustine, Lamustine

26
Q

What two drugs are nephro and ototoxic

A

Cisplatin, ototoxic

27
Q

Cardio toxicity

A

Doxorubicin, and anthracyclines

28
Q

Methotrexate

A

Mucositis

29
Q

Hemorhagic cystitis

A

Nitrosuruea

Carmustine, Lamustine

Ifosfamide, Cyclophosphamide

30
Q

Peripheral neuropathy

A

Vincas, Taxanes

31
Q

What adjunctive medication is used for cisplatin and what does it prevent?

A

Amifostine (Ethyol)

32
Q

What adjunctive medications are used for doxorubicin and what does it prevent?

A

Dextrazoxane (Zinecard) To prevent cardiomyopathy

Dextrazoxane (Totect) to treat extravasation

33
Q

What is given with fluorouracil adn what does it do?

A

Leucovorin to enhance efficacy

34
Q

What is the antidote for fluorouracil and capecitabine?

A

Uridine triacetate

35
Q

What is added to ifosfamide and what is it for?

A

Mesna to prevent hemorrhagic cystitis

36
Q

What can you do with cisplatin and ifosfamide?

A

Cisplatin to prevent nephrotoxicity

Ifosfamide to prevent cystitis

NAPLEX (64 decks)

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