Hepatitis Keys and Brand/generic

Question 1

Mechanism of action of drugs ending in previr?

4 examples

Answer 1

NS3/4A protease inhibitors

Grazoprevir

Paritaprevir

Simeprevir

Vaxilaprevir

Question 2

Mechanism of action of drugs ending in asvir 5 examples

Answer 2

NS5AReplication complex inhibitor

A for NS5A

Daclatasvir

Ledipasvir

Ombitasvir

Pibrentasvir

Velpastasvir

Question 3

Harvoni

Answer 3

Sofosbuvir/Ledipasvir

Question 4

Epclusa

Answer 4

Sofosbuvir/Velpatasvir

Question 5

Viread

Answer 5

Tenofovir Disoproxil

Question 6

Vimlidy

Answer 6

Tenofovir Alfenamide

Question 7

For all HBV NRTI drugs what is the dosing cut off?

And what are the 2 big warnings?

Answer 7

At CrCl<50 decrease dosing frequency vamildy has a different cut off at 15

• Boxed warning for lactic acidosis and severe hepatomegaly with steotosis
• And exacerbation of HBV

Question 8

WHat types of lamivudine are not interchangeable?

Answer 8

Epivir HBV tablets and oral solution are not interchangeable

Question 9

All DAAs are contraindicated with what?

what are the 7 examples?

Answer 9

COntraindicated with strong inducers of CYP3A4

1. Carbamazepine
2. Oxcarb
3. Phenobarb
4. Phenytoin
5. Rifampin
6. Rifabutin
7. St johns wart

Question 10

Harvoni Epclusa and Vosevi all contain?

Answer 10

Sofosbuvir

Question 11

Harvoni Epclusa and Vosevi Drug interactions?

Answer 11

• Antacids, H2RAs, PPIs, can decrease concentrations of ledipasvir and velpatasvir
• Separate antacids by 4 hours
• H2RAs at the same time or sep by 12 hours
• Using PPIs with epclusa is not recommended