Alcoholic Liver Disease Flashcards Preview

OSCE Conditions > Alcoholic Liver Disease > Flashcards

Flashcards in Alcoholic Liver Disease Deck (6):
1

Symptoms of alcoholic liver disease

Reduced appetite
Diarrhoea
Puritis

2

Signs of alcoholic liver disease

Jaundice
Signs of anaemia
Palmar erythema
Portal hypertension signs: oesophageal varices, ascites, splenomegaly, caput medusae, spider navi
Bruising (low clotting factors)

3

Investigations of alcoholic liver disease

LFTS: high AST/ALT, high ALP, high bilirubin

FBC: low albumin, anaemia, deranged clottingㄷ

4

Management of alcoholic liver disease

Lifestyle advice: stop drinking alcohol

Disulphram used in chronic alcohol dependence (inhibits aldehyde dehydrogenase)

Treat complications (anaemia etc.)

Liver transplant

5

Complications of alcoholic liver disease

Liver failure
Hepatocellular carcinoma
Encephalopathy
Dementia
Epilepsy

6

Pathophysiology of alcoholic liver disease

Excessive alcohol depletes NAD+, can't be used for fatty acid oxidation or conversion of lactate to pyruvate.
Increased NADH also promotes fat storage
Acetaldehyde is toxic to hepatocytes, decreases protein production and fat transport.

Fat builds up in liver -> alcoholic steatosis -> liver fibrosis -> alcoholic cirrhosis