Thyroid Disease Flashcards Preview

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Flashcards in Thyroid Disease Deck (7):
1

Symptoms of hypothyroidism

Tiredness
Cold intolerance
Weight gain
Depression
Dry skin and hair

2

Pathophysiology of hyperthyroidism

Graves' disease = autoimmune
Auto antibody binds to TSH receptors on thyroid follicles, stimulate increased thyroid release

Can also be due to thyroid/pituitary adenoma, hypothalamic dysfunction or thyroid nodules

3

Pathophysiology of hypothyroidism

Hashimotos disease: autoantibody blocks TSH receptor, leads to destruction of thyroid cell and less thyroid hormone release.

Can also be due to pituitary/hypothalamic dysfunction or iodine deficiency

4

Investigations of thyroid disease

Thyroid function tests - measure T3/T4/TSH levels

5

Management of thyroid disease

Hyperthyroid: give carbimazole - prevents thyroid peroxidase enzyme from iodinating tyrosine residues, so reduces thyroxine production

Hypothyroidism: give hormone replacement - levothyroxine

6

Complications of thyroid disease

Thyroid eye disease -> red, swollen, retracted eyelids, bulging eyes, dryness, double vision

Pregnancy problems: pre-eclampsia, miscarriage, premature birth

Atrial fibrillation, heart failure

Goitre

7

Symptoms of hyperthyroidism

Heat intolerance
Tiredness
Anxiety and irritability
Goitre
Difficulty sleeping
Palpitations
Weight loss