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Flashcards in ALL - Krafts Deck (9)
1

Define Acute Lymphoblastic Leukemia

Malignant proliferation of lymphoid blasts in the blood and bone marrow

2

What are the characteristics of ALL?

Classified by immunophenotype: B vs. T-cells
More common in children
Good prognosis

3

Which type of ALL has a worse prognosis?

T-lymphoblastic leukemia

4

What markers do you look for in T-lymphoblastic Leukemia?

TdT
T-Cell Antigens for CD3,4,5,7,8

5

What markers do you look for in B-lymphoblastic Leukemia?

TdT
B-cell Antigens for CD19,20,21

6

T-Lymphoblastic Leukemia/Lymphoma Characteristics

Teenage male with mediastinal mass (Thymus)
HIGH WBC count
Poor Prognosis

7

B-Lymphoblastic Leukemia/Lymphoma Characteristics

TdT +
MOST common in Children

8

ALL Prognosis

T-Lymphoblastic is worse = make sure to Immunophenotype!!
Age 1-10 has Good Prognosis
Reasonable WBC count (

9

ALL Treatment

Chemotherapy
Possibly Bone Marrow Transplant
Curative without Bone Marrow Transplant