Antineoplastics II: Drugs that Prevent DNA Synthesis - Fitz Flashcards Preview

IHO Week 3 > Antineoplastics II: Drugs that Prevent DNA Synthesis - Fitz > Flashcards

Flashcards in Antineoplastics II: Drugs that Prevent DNA Synthesis - Fitz Deck (7)
1

Define Antimetabolites

Analogues of folate, pyrimidine or purine that interfere with DNA synthesis

2

What is the common mechanism for development of resistance in antimetabolites?

Changes in Target Enzymes

3

What type of cell cycle agents are antimetabolites?

Cell Cycle Specific S-Phase

4

What is Tumor Lysis Syndrome?

Development of electrolyte and metabolic disturbances that can produce life-threatening complications (hyperuricemia)

5

Why is Allopurinol frequently used during chemotherapy of hematologic cancers?

Allopurinol is a xanthine oxidase inhibitor used to prevent hyperuricemia due to tumor lysis syndrome

6

PRPP + hypoxanthine =

IMP

7

PRPP + guanine =

GMP