Flashcards in Antineoplastics II: Drugs that Prevent DNA Synthesis - Fitz Deck (7)
Analogues of folate, pyrimidine or purine that interfere with DNA synthesis
What is the common mechanism for development of resistance in antimetabolites?
Changes in Target Enzymes
What type of cell cycle agents are antimetabolites?
Cell Cycle Specific S-Phase
What is Tumor Lysis Syndrome?
Development of electrolyte and metabolic disturbances that can produce life-threatening complications (hyperuricemia)
Why is Allopurinol frequently used during chemotherapy of hematologic cancers?
Allopurinol is a xanthine oxidase inhibitor used to prevent hyperuricemia due to tumor lysis syndrome
PRPP + hypoxanthine =