Antineoplastics III: Drugs that Disrupt DNA Flashcards Preview

IHO Week 3 > Antineoplastics III: Drugs that Disrupt DNA > Flashcards

Flashcards in Antineoplastics III: Drugs that Disrupt DNA Deck (6)
1

What drug is hemorrhagic cystitis associated with?

Cyclophosphamide

2

What class of drugs is cardiomyopathy associated with?

Anthracycline Antibiotics

3

What are the cytotoxic drug side effects?

Bone marrow suppression
Gastritis
Alopecia

4

What type of cell cycle agents are drugs that damage or disrupt DNA?

Cell Cycle Non-Specific

5

When does primary toxicity occur in the cell cycle for drugs that damage or disrupt DNA?

Late G1 and S Phase

6

What is the mechanism of action for alkylating agents?

Activation to an electrophile --> N7 Guanine Nucleophilic Attack --> Damage DNA