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Flashcards in Bone Tumors Deck (21)
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1

What is an osteoma?

benign slow growing tumor
- painful lesion

2

What makes up an osteoma?

osseous tissue and surrounded by a halo of reactive bone formation

3

Where are osteomas most commonly seen?

skull, facial bones, and sinus cavities, impinging on the brain/eyes

4

Osteoid osteoma is most commonly seen in what age group?

5-25 years
(boys to girls, 3:1)

5

What is Osteoid osteoma composed of microscopically?

thin, irregular trabeculae of woven bone
- treated with surgery or radio ablation

6

What is osteoblastoma?

uncommon and benign neoplasm

7

Osteoblastoma is characterized by what?

woven bone trabeculae and osteoid, sined by osteoblasts, and inrabecular spaced are filled by loose CT

8

Osteoblastoma mostly affects what groups?

20-30 yo, no sex preference

9

Which bone disease affects people under 25, 75 % of the time?

- osteoid osteoma
- boys and long bones more often
- very painful

10

What is the most common primary bone tumor? (after myeloma and lymphoma)

osteosarcoma

11

What are the characteristics of osteosarcoma?

- primary in under 20 yo, secondary in elders
- men more often
- usually seen in metaphyseal region

12

What gene mutations cause osteosarcoma?

- gene of retinoblastoma (RB)
- p53

13

What conditions can lead to osteosarcoma?

- Pagets
- bone infarcts
- osteochondroma
- enchondroma
- fibrous dysplasia

14

histo and micro for Osteosarcoma

- bulky/gritty tumors
- raised periosteum

15

small cell osteosarcomas

- resembe cells of Ewings sarcoma

16

Telangiectatic osteosarcomas

- tumors of long tubular bones

17

intracortical osteosarcoma

- rare
- in cortex of an osteolytic lesion

18

what can be elevated in osteosarcoma?

-serum alkaline phosphatase (1/2 of people)

19

Codman triangle

- periosteal reaction
- aggressive processes
- advancing tumor destroys periosteum
- CAUSED by stress fracture, infection, or osteoma

20

Osteochondroma

- benign cartiagenous growth attached to the bone with a body stalk ( exostosis)
- displacement of the cartilage
- ALSO called enchondromas

21

Ollier's disease

- multiple enchondromas throughout the skeleton