Flashcards in Myopathies and Soft Tissue Deck (32)
Provide tumor name for the fallowing..
- smooth muslce
- skeletal muslce
smooth muslce - leiomyoma
skeletal muslce - Rhabdomyoma
lipocytes - lipoma
firbroblasts - fibroma
vascular - hemangioma
What are the non-neoplastic conditions?
nodular fascitis, myositis ossifacans, and fibromatosis
- commonly encapsulated
- subcutaneous tissue (proximal extrem and trunk)
- treated by Excision
- deep/large in proximal extrem and retroperitoneum
malignant fibro sarcoma
fibrohistoiocytoma is found where?
dermis and subcutaneous in adults
Where is leiomyoma usually found?
what age for rhabdomyoma?
malignant rhabdomyosarcoma is usually found where?
head and neck
What are the fibrous tumor-like conditions?
- nodular fasciitis
- myositis ossificans
composed of fibroblasts and mimic sarcomas histologically
- most common
- plump randomly oriented spindle cells with myxoid stroma
- reatment by excision
myositis ossificans (stiff man syndrome)
- CT and m. is replaced by bone
- seen in athletes, adolescents, and young adults
- in dermis, LE muscles
What is the name for myositis ossificans found in the adductors?
- Prussian's disease
What are the common areas for fribromatosis?
- Palmar and plantar fascia
- more common in males
What are the two most common types of muscular dystrophies?
Duchenne type MD
- x-linked and mostly in males
- absence of Dystrophin
- pelvic girdle mm. --> shoulder girdle mm.
- compensatory hypertrophy
What is high in Duchenne type MD?
- less common and less severe than Duchenne
- no mental retardation
- AUTOSOMAL DOMINANT
- 10-30 years
- heart is not involved and CPK is normal
Ocular-pharyngeal muscular dystrophy
- autosomal dominant
- extraocular and facial m. weakness
- ptosis and dysphagia
type 1 - autosomal dominant
type 2 - autosomal recessive
- slow progression
- CPK is less elevated
- autosomal dominant
- myotonia - sustained involuntary contraction
- 2-4th decade
what are some of the clinical findings in myotonic dystrophy?
mental retardation, apathy, hypersomnia, and mild sensory neuropathy
- autosomal recessive
- lipid vacuoles in muslces
- progressive muslce weakness
- chronic progressive ophthalmoplegia
- kearns-Sayre syndrome
- glycogen and mucopolysaccharide accumulation
- atrophy, cramping, and muslce aching
- slow movements and reflexes
drug induced myopathy