Myopathies and Soft Tissue Flashcards Preview

Systems Pathology l > Myopathies and Soft Tissue > Flashcards

Flashcards in Myopathies and Soft Tissue Deck (32)
Loading flashcards...
1

Provide tumor name for the fallowing..
- smooth muslce
- skeletal muslce
- lipocytes
- firbroblasts
-vascular
-

smooth muslce - leiomyoma
skeletal muslce - Rhabdomyoma
lipocytes - lipoma
firbroblasts - fibroma
vascular - hemangioma

2

What are the non-neoplastic conditions?

nodular fascitis, myositis ossifacans, and fibromatosis

3

benign lipoma

- Adult
- commonly encapsulated
- subcutaneous tissue (proximal extrem and trunk)
- treated by Excision

4

malignant liposarcoma

- nonencapsulated
- deep/large in proximal extrem and retroperitoneum

5

malignant fibro sarcoma

palisadig appearance

6

fibrohistoiocytoma is found where?

dermis and subcutaneous in adults

7

Where is leiomyoma usually found?

uterus

8

what age for rhabdomyoma?

before 20

9

malignant rhabdomyosarcoma is usually found where?

head and neck

10

What are the fibrous tumor-like conditions?

- nodular fasciitis
- myositis ossificans
- fibromatosis

11

reactive pseudosarcoma

composed of fibroblasts and mimic sarcomas histologically

12

nodular fascitis

- most common
- plump randomly oriented spindle cells with myxoid stroma
- reatment by excision

13

myositis ossificans (stiff man syndrome)

- CT and m. is replaced by bone
- seen in athletes, adolescents, and young adults
- in dermis, LE muscles

14

What is the name for myositis ossificans found in the adductors?

- Prussian's disease

15

What are the common areas for fribromatosis?

- Palmar and plantar fascia
- more common in males

16

What are the two most common types of muscular dystrophies?

- Duchenne
- Becker

17

Duchenne type MD

- x-linked and mostly in males
- absence of Dystrophin
- pelvic girdle mm. --> shoulder girdle mm.
- compensatory hypertrophy

18

What is high in Duchenne type MD?

CPK

19

Beckers

- less common and less severe than Duchenne
- no mental retardation

20

Fascioscapulohumeral MD

- AUTOSOMAL DOMINANT
- 10-30 years
- heart is not involved and CPK is normal

21

Ocular-pharyngeal muscular dystrophy

- autosomal dominant
- extraocular and facial m. weakness
- ptosis and dysphagia

22

limb-girdle MD

type 1 - autosomal dominant
type 2 - autosomal recessive
- slow progression
- CPK is less elevated

23

myotonic dystrophy

- autosomal dominant
- myotonia - sustained involuntary contraction
- 2-4th decade

24

what are some of the clinical findings in myotonic dystrophy?

mental retardation, apathy, hypersomnia, and mild sensory neuropathy

25

congenital myopathies

- autosomal recessive
- hypotonia

26

lipid myopathies

- lipid vacuoles in muslces
- progressive muslce weakness

27

mitochondrial myopathies

- chronic progressive ophthalmoplegia
- kearns-Sayre syndrome

28

hypothyroidism

- glycogen and mucopolysaccharide accumulation
- atrophy, cramping, and muslce aching
- slow movements and reflexes

29

drug induced myopathy

- steroids
- statins

30

What is Myasthenia Gravis?

- autoimmune disorder: type ll hypersensitivity that is antibody mediated
- 3 : 100, 000