Ch. 338 Flashcards Preview

Nelson - The Digestive System > Ch. 338 > Flashcards

Flashcards in Ch. 338 Deck (27):
1

Specific findings on examination can guide toward a specific malabsorption disorder: Edema

Protein-losing enteropathy

2

Specific findings on examination can guide toward a specific malabsorption disorder: Digital clubbing

CF and celiac disease

3

Specific findings on examination can guide toward a specific malabsorption disorder: Perianal excoriation and gastric abdominal distension

Carb malabsorption

4

Specific findings on examination can guide toward a specific malabsorption disorder: Perianal and circumoral rash

Acrodermatitis enteropathica

5

Specific findings on examination can guide toward a specific malabsorption disorder: Abnormal hair

Menke syndrome

6

Clinitest reagent is used for screening carb malabsorption which identifies reducing substances such as carbs in stool. A positive test is

An acidic stool with >2+ reducing substance

7

___ is used to identify the specific carbohydrate that is malabsorbed

Breath hydrogen test

8

Procedure in Breath hydrogen test

After an overnight fast, the suspected sugar is administered as an oral solu­tion. A rise in breath hydrogen of 20 ppm above the baseline is considered a positive test. The child should not be on antibiotics at the time of the test, because colonic flora is essential for fermenting the sugar.

9

a sensitive test to assess exocrine pan­ creatic function in chronic cystic fibrosis and pancreatitis

Fecal elastase-1

10

Main clinical expression of malabsorption

Diarrhea

11

Investigation for carb malabsorption: Can measure mucosal disaccharidase concentrations directly

Small bowel mucosal biopsies

12

MCC of hypoalbuminemia in children

Renal disorder

13

Measurement of ___ is a useful screening test for protein-losing enteropathy

alpha1-antitrypsin

14

MCC of exocrine pancreatic insufficiency

Cystic fibrosis

15

Gold standard for exocrine pancreatic function

Direct analysis of duodenal aspirate (volume, bicarb, trypsin, and lipase upon secretin and pancreozymin/cholecystokinin stimulation)

16

Gluten-sensitive enteropathy

Celiac disease

17

Immune-mediated disorder characterized by chronic inflammation of the small intestine

Celiac disease

18

Antibodies seen in Celiac disease

Antibodies to TG2

19

MC extraintestinal manifesration of celiac disease

IDA unresponsive to iron therapy

20

Ultimate diagnosis of celiac disease relies on

Demonstration of specific but not pathognomonic histopathologic abnormalities in the small bowel mucosa

21

ESPHAN Criteria for celiac disease

1) Villous atrophy with hyperplasia of the crypts and abnormal surface epithelium while patient is eating adequate amounts of gluten 2) Full clinical remission after withdrawal of gluten from diet

22

The only treatment for celiac disease

Lifelong strict adherence to a gluten-free diet

23

Short bowel syndrome is the loss of >___% of small bowel with or without a portion of the large intestine

50

24

Main site for carb, protein, iron, water-soluble vitamin absorption

Proximal 100-200cm of jejunum

25

Vitamin B12 and bile salts are only absorbed in

Distal ileum

26

Primary adult type hypolactasia is caused by

Physiologic decline in lactase activity that occurs following weaning in most mammals

27

Secondary lactose intolerance is caused by

Small bowel mucosal damage, usually transient improving with mucosal healing