Portal hypertension Flashcards Preview

Nelson - The Digestive System > Portal hypertension > Flashcards

Flashcards in Portal hypertension Deck (14):
1

Portal hypertension is defined as elevation of portal pressure

>10-12mmHg

2

Normal portal venous pressure

~7mmHg

3

Portal htn can result from obstruction to portal blood flow anywhere along the course of

Portal venous system

4

T/F Portal vein thrombosis is associated with hypercoagulable states such as deficiencies of factor V Leiden, protein C, or protein S

T

5

Predominant cause of portal htn and is related to obstruction of blood flow through the portal vein

Cirrhosis

6

Occurs with obstruction to hepatic veins anywhere between the efferent hepatic veins and entry of the IVC into the right atrium

Budd-Chiari Syndrome

7

MCC of hepatic vein obstruction in children

Sinusoidal obstruction syndrome (veno-occlusive disease)

8

MC presentation of portal vein obstruction

Bleeding from esophageal varices

9

2nd most common presenting feature of portal vein obstruction

Splenomegaly, sometimes with hypersplenism

10

Hepatopulmonary syndrome develops in ≥10% of patients with cirrhosis and is defined as

PaO2 defect induced by intrapulmonary microvascular dilatation, resulting from the release of mediators such as NO into the venous circulation

11

Flow through the portal vein associated with variceal bleeding

Hepatofugal flow

12

Most reliable method for detecting esophageal varices and for identifying source of GI bleeding

Endoscopy

13

MOA of vasopressin in variceal bleeding

Increases splanchnic vascular tone thus decerasing portal blood flow

14

TIPS involves placing a stent between the

Right hepatic vein and right or left branch of the portal vein