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Flashcards in Clinical Deck (97)
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1

This is the early bone marrow hematopoietic cell.

Blast cell

2

What happend to bone marrow to cause acute leukemia?

Failure

3

What are the 3 markeres for AML?

CD13, CD33, MPO

4

Do mainly kids or adults get AML?

Adults

5

What 2 conditions can make u eligable for stem cell transplant for the treatment of AML?

< 65 y/o
HLA matching a sibling donor

6

What is the main detereminant for therapy for AML?

age

7

What is the regiment for AML therapy?

4 blocks, each about 1 wk

8

What is the treatment if a hemorrhagic syndrome develops in promyelocytic variant AML?

platelets with FFP

9

What drug can cause the prolfieration of N0 that follows differentiation of promyelocytes from the bone marrow?

ATRA

10

What is the treatment of ATRA syndrome?

Dexamethasone

11

What do u treat the elderly with in AML over 70?

supportive care with or without gentle single-drug chemo

12

What is the treatment options for relapsed AML?

Further chemo
stem cell transplant if tolerable and have a donor
arsenic trioxide for relapsed M3 variant

13

This is teh small # of leukemic cells that remain in the pt during treament, or during remission.

Minimal residual disease (MRD)

14

What can MRD do?

cause relpase in cancer and leukemia

15

Are chronic or acute leukemias harder to treat?

Chronic

16

What % of leukemias are CML?

15%

17

What is the gene mutation in CML?

t(9;22)

18

What age range is at risk for CML?

40-60

19

Which organ is enlarged in CML?

Spleen

20

What is the drug that is used to treat CML by blocking tyrosine kinase activity?

Imatinib (glivec)

21

What is the optimal response to imatinib?

complete cytogenic response

22

If the pt has a suboptimal response to imatinib in the Tx of CML, what other 2 drugs can u give?

Dasatinib

Nilotinib

23

What do Dasatinib and Nilotinib do to help Tx CML?

overcome resistance to imatinib or early allogenic stem cell transplant

24

What is the overall survival rate in CML pts in the Tx with imatinib?

89%

25

What does hydroxyurea do to help CML pts?

it can control and maintain the white cell count in chronic phase

26

How long do u have to take hydroxyurea in the Tx of CML?

Forever.

27

After the white cell count has been controlled by hydroxyurea, what has been used to keep the white cell count low?

a-interferon

28

Waht is the only established curative treatment for CML?

Allogenic stem cell transplant

29

What are the 2 reservations for the use of stem cell transplant for CML Tx?

if u fail with imatinib and are < 65 y/o

30

This is when there is 20% or more blasts in the marrow and may occur rapidly over days or weeks.

Acute transofrmation