Flashcards in Microbiology Deck (61)
What is the CD receptor on B cells where EBV infections?
Where are the 2 locations of epithelial cells that are infected by EBV?
Oro and nasopahrynx
Which cells does EBV reside in for latent EBV?
Memory B cells
After the EBV virus binds to the C3d receptor, what happens to the B cells?
Which proteins do B cells express after being stimualted to grow? (4)
LMPs 1 and 2
Which B cell proteins are DNA binding protiens that are essential for establishing an maintaining the infection?
Which protein from the B cells is a membrane protein with oncogene-like activities?
This is the B Cell protein that is transcribed and translated during early genes of the virus and the lytic cycle.
ZEBRA transcriptional activator protein
What is the viral attachement protein that promote fusion of the envelope with the cell membrane, which occurs after the synthesis of DNA polymerase and replication of DNA?
When do you see the anti EBNA marker?
After resolution of infection
When do you see the early Ag?
After an infected cell has entered lytic cycle
What are the 2 components of the late VCA protein, which is found in virus-producing cells?
Anti-VCA IgM = transient
Anti-VCA IgG = persistent
When do you see the membrane Ag?
same as VCA - late protein, in virus producing cells
When do you see the Heterophile Ab?
Early, where EBV induces B cell proliferation
An overactive immune response (from T cell) to EBV infection can produce what problem?
Infectious mononucleosis (IM)
So what are the 2 problems if there is lack of effecting immune control of EBV infections?
Hairy cell leukoplakia
What is the transmission method for EBV?
Slaiva (kiss kiss)
These are the atypical lymphocytes made when Tc cells controls B-cell proliferation, induced by EBV.
Is EBV heteophile + or -?
The B cell activation and proliferation causes a false production of IgM to what Ag, which screens for heterophiles?
True or False: a good way of distinguising EBV from CMV infections is to see if there are Downey cells, as they'e only present in EBV infecitons.
Theyre in both, but mostly in EBV infections.
This is there condition where there is heterophile +, Sx similar to strep pharyngitis (gray/green throat exudate), extreme fatigue, lympadenopathy, exydate pharyngitis, splenomegaly and splenic rupture.
Treatment of IM with what drug can cause an erythematous rask because of an allergic rxn?
What are the 2 main complicaitons to IM?
What age group is at most risk for IM?
Which pts are at highest risk for life-threatening neoplastic disease in IM?
This is the stage of IM where you see heterophile Ab present, mono symptoms, no EBNA, VCA IgM/IgG present, and possible EA.
Which of the following markers are present during the Chronic form of IM?
Heterophile Ab, VCA IgM or EBNA, VCA IgG, EA
VCA IgG and EA
Which of the following markers are present during the latent form of IM?
Heterophile Ab, VCA IgM, VCA IgA, EBNA, VCA IgG, EA