Flashcards in Diabetic Drugs Deck (18)
Give an example of a sulphonylurea.
tolbutamide, glibenclamide, glipizide
Give an example of a glinide?
Give an example of DPP-4 inhibitor.
Give an example of a GLP-1 agonist.
Give an example of an a-glucosidase inhibitor.
Give an example of a biguanide.
Give an example of a TZD.
Give an example of an SGLT2 inhibitor.
How do sulphonylureas work?
affect ADP-Mg binding to SUR1, causing the channel to close and insulin to be released INDEPENDENT of glucose concentration
How do DPP-4 inhibitors work?
competitive inhibition of DPP-4 enzyme, terminating action og GLP-1 and GIP
How do biguanides work?
reduce hepatic gluconeogenesis by stimulating AMP-activated protein kinase.
What do biguanides increase?
fatty acid oxidation
glucose uptake and use by skeletal muscle
What do biguanides decrease?
List the cons of sulfonylureas.
When should sulfonylureas be avoided?
(Don't use first line in obese)
Do DPP-4 inhibitors cause weight loss or gain?
neither, weight neutral
Is metformin safe in pregnancy?