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Flashcards in Ovulation Disorders Deck (11)
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Define oligomenorrheoea.

reduction in frequency of periods to less than 9/year


Define primary amenorrhea.

failure of menarche to occur by age 16


Define secondary amenorrhea.

cessation of periods for >6months in individual who has previously menstruated


What should you consider in primary amenorrhea?

Consider congenital problems (Turner’s syndrome, Kallman’s syndrome)


Describe some causes of secondary amenorrhea?

Ovarian problem: PCOS, Premature Ovarian Failure
Uterine problem: uterine adhesions
Hypothalamic Dysfunction: weight loss, over exercise, stress, infiltrative
Pituitary: high PRL, hypopituitarism


Describe premature ovarian failure.

Amenorrhea, oestrogen deficiency and elevated gonadotrophins occuring < 40years of age, as a result of loss of ovarian function


Describe causes of POF.

Chromosomal abnormalities (e.g. Turner’s syndrome, Fragile X)
Gene mutations (e.g. FSH receptor/LH receptor)
Autoimmune disease (e.g. association with Addison’s, thyroid, APS1/2)
Iatrogenic (radiotherapy/chemotherapy)


What is secondary hypogonadism?

Hypogonadism as a result of hypothalamic or pituitary disease
Characterised by low oestradiol with low/normal LH/FSH


What is hursitism and what causes it?

excess hair; usually used when referring to women with male pattern hair distribution
Caused by androgen excess at the hair follicle
Due to excess circulating androgen
Due to increased peripheral conversion at the hair follicle


What is the most common cause of huristism?



What is congenital adrenal hyperplasia?

CAH is an inherited group of disorders characterised by a deficiency in one of the enzymes necessary for cortisol synthesis