Hypo/hyperthyroidism Flashcards Preview

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Flashcards in Hypo/hyperthyroidism Deck (58)
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1

Give 2 secondary causes of hypo/hyperthyroidism?

hypothalamic
pituitary

2

What would you want to measure if you thought a patient has hyperthyroidism?

thyroid function tests
also do ECG in case of AF

3

What is pretibial myoxoedema? When is it seen?

accumulation of mucopolysaccharides in ground substance of dermis on skin of shins
Grave's disease

4

What is thyrotoxicosis?

hyperthyroidism

5

When does myoexedema occur?

Either refers to severe hypothyroidism eg myoexedema coma
OR pretibial myoxoedema in Grave's disease - on skin

6

In areas of high iodine intake, is hypo or hyper more common?

hypo

7

What are the goitrous causes of primary hypothyroidism?

Chronic thyroiditis (Hashimotos)
Iodine deficiency

8

What are the non goitrous causes of hypothyroidism?

atrophic thyroiditis
post ablative/radiotherapy
congenital

9

Most common cause of thyroiditis?

hashimoto's

10

In Hashimotos, what is seen in blood?

thyroid peroxidase antibodies

11

In Hashimotos, what is seen on microscopy?

T cell infiltrate and inflammation

12

What type of hair can be seen in hypothyroidism?

sparse, coarse

13

What are other signs of hypothyroidism?

dull expressionless face
periorbital puffiness
pale cool skin, doughy to touch
vitiligo
hypercarotenaemia/yellowing
fluid retention, pitting oedemia

14

Can vitiligo be associated with hypo or hyper?

hypo

15

What happens to heart rate in hypo?

reduced

16

What happens to lipids in hypo?

hyperlipidaemia

17

What respiratory signs may occur with hypo

deep hoarse voice, macroglossia, obstructive sleep apnoea

18

What GI symptoms may occur with hypo?

constipation

19

What is carpal tunnel more likely in, hypothyroid or hyperthyroid?

hypo

20

What can hypothyroidism do to periods?

menorrhagia
later oligo/amenorrhoea

21

What does hypothyroid do to prolactin?

increases

22

What happens to thyroid hormones in hypothyroid?

TSH high
T4/3 low

23

What happens to sodium in hypothyroidism?

low

24

Once stabilized, how often should TSH be checked?

every 12-18 months

25

What is the main treatment of hypothy.

thyroxine

26

Is there any benefit of combined T4 and T3 therapy?

no

27

When is T4 preferabnly taken?

before breakfast

28

Is T3 therapy used much in hypo?

no

29

Who does myxoedema coma tend to affect?

elderly women with longstanding but untreated hypothyroidism

30

Is there a high mortality in myxoedema coma?

yes