MICRO102A > ENTEROBACTERIACEAE - E. COLI > Flashcards

ENTEROBACTERIACEAE - E. COLI Flashcards

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1
Q

Name this disease in poultry caused by E. coli: (includes pathogenesis + clinical signs + target host)

  • Primarily respiratory tract-> bloodstream -> acute colisepticemia, fibropurulent serositis, coligranuloma (chronic disease characterized by granulomatous lesions in the wall of the intestinal tract, liver and lungs
A

Coligranuloma - Hjarre’s Disease

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2
Q

Both STa and STb are insoluble and no biological activity in suckling mice. True or False?

A

False, only STb

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3
Q

Name this disease in swine caused by E. coli: (includes pathogenesis + clinical signs + target host)

  • After weaning
  • Bowel edema
  • Colonization -> release of edema disease (ED) toxin -> bloodstream -> small arteries -> mural edema, hyaline degeneration, permeable to fluid
  • ED toxin vasotoxin -> hypertensive
A

Edema disease

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4
Q

Shiga-like toxin structurally resembles cytotoxin of ?

A

Shigella dysenteriae type 1 (Shiga)

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5
Q

Give the E. coli strain (that causes enteritis) with the given data:

  • Colonize the intestine
  • Produce Shiga-like toxins and destroy microvilli layers
A

AEEC - attaching and effacing E. coli

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6
Q

Shiga-like toxin contains A and B subunits. Between the two, which has toxin-binding function?

A

B subunits

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7
Q

Name this disease in poultry caused by E. coli: (includes pathogenesis + clinical signs + target host)

  • Diarrhea due to urinary water loss and not (?) sequel of enteritis
A

Avian colibacillosis

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8
Q

What are the benefits of harmless strains of E.coli to the body?

A
  1. Produces vitamin K
  2. Prevent establishment of pathogenic bacteria within the intestine
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9
Q

What are the antigens present in the members of Family Enterobacteriaceae?

A
  1. K (capsular antigen) - capsular polyscaccharide particularly heavy in Klebsiella
  2. H (flagellar) antigen - flagellar proteins of motile genera and species
  3. O (somatic) antigen - O-specific polysaccharide chain of lipopolysaccharide.
  4. Vi - capsule of Salmonella
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10
Q

STb (enterotoxin) is found in enterotoxigenic E. coli from ____ _____.

A

weanling pigs

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11
Q

What are the end effects of Edema disease toxin?

A

1.Hypertension
2. Panarteritis

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12
Q

Enterotoxin of E. coli consisting 2 dissimilar polypeptide subunits A and B -> 5B and 1A subunit in each entire toxin molecule.

A

LT enterotoxin

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13
Q

Give the different non-lactose fermenters under Family Enterobacteriaceae.

A

*** ShHYPS
1. Shigella
2. Yersinia
3. Proteus
4. Salmonella

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14
Q

Give the E. coli strain (that causes enteritis) with the given data:

  • Produce enterotoxins
  • Uses fimbrial adhesins to bind to enterocytes in the small
    intestines
  • Produces 2 proteinaceous enterotoxins:
    a. LT – similar to cholera toxins
    b. ST – cGMP accumulation in the target cells and subsequent secretion of fluids and electrolytes into intestinal lumen
  • Non-invasive, do not leave intestinal lumen
A

ETEC - enterotoxigenic E. coli

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15
Q

Give the E. coli strain (that causes enteritis) with the given data:

  • Do not produce enterotoxins or Shiga-like toxins and cause
    enteritis by other unknown mechanism
  • Use adhesins known as intimin to bind host intestinal cells
  • Virulence factor similar to Shigella
  • Adherence to intestinal mucosa causes rearrangement of actin
    in host cell causing deformation
  • Moderately invasive and elicits an immune response
  • Changes in intestinal cell ultrastructure due to attachment and effacement is likely to cause diarrhea
A

EPEC - enteropathogenic E. coli

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16
Q

What is the major route of E. coli?

A

Feco-oral route

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17
Q

Certain strains of E. coli such as _____ produce lethal toxins.

A

O157:H7

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18
Q

Some of members of Family Enterobacteriaceae ferments glucose with acid production. True or False?

A

False, all members

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19
Q

STa (enterotoxin) is found in enterotoxigenic E. coli from _____ _____.

A

baby piglets

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20
Q

What are the antigens of E. coli?

A
  1. O
  2. K
  3. H
  4. F
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21
Q

Edema disease toxins produce ____ and _____ in mice and toxic changes in _____ cells.

A

paralysis and death; Vero

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22
Q

Name the diseases induced by E. coli in rabbits.

A
  1. Cecitis
  2. Diarrhea
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23
Q

Family Enterobacteriaceae is oxidase _____, catalase ______.

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A

negative; positive

24
Q

Name this disease in cattle caused by E. coli: (includes pathogenesis + clinical signs + target host)

  • White scours, during first week of life
  • Severe diarrhea with feces full of gas bubbles
  • Die in a few days due to dehydration and acidosis
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A

Enteric disease

25
Discuss the mechanism of action of LT toxin of E. coli.
B subunits bind to gangliosides GM1 on mucoid cells on the intestines -> subunit A activates adenylate cyclase by NAD-dependent ADP ribosylation of its regulatory subunits -> levels of intracellular cyclic AMP increase which causes a net outflow of Na, Cl and water from cell
26
Give other 5 members of Family Enterobacteriaceae.
1. Morganella morganii (form. Proteus morganii/Providencia) 2. Providencia spp. 3. Serratia spp. 4. Erwinia 5. Opportunistic Enterobacteriaceae 6. Citrobacter 7. Enterobacter 8. Serratia 9. Edwardsiella
27
Name the diseases induced by E. coli in **horse**.
1. Abortion in mares 2. Congenitally abnormal foals unable to suckle, die within 24 H
28
Edema disease toxin is insoluble at _____ pH but soluble at _____ pH.
acidic; alkaline
29
Edema disease toxin can inhibit protein synthesis in endothelial cells of blood vessels. True or False?
True
30
STa (enterotoxin) is soluble in _____ and has biological activity in suckling mice.
methanol
31
Proteinaceous protein/toxin produced by most enteropathogenic E, coli from enteritis in human infants.
Shiga-like toxin (SLT)
32
Name this disease in **swine** caused by E. coli: (includes pathogenesis + clinical signs + target host) * Shortly after weaning * Hemolytic E. coli * Change of diet leads to massive colonization of anterior small intestine * Persists for 2 to 3 days, pigs collapse and die after short period of diarrhea * Net efflux of sodium, water, bicarbonate and chloride into bowel lumen
Weanling enteritis
33
Name this disease in **lambs** caused by E. coli: (includes pathogenesis + clinical signs + target host) * Can induce enteric diarrhea * Can induce bacteremic diarrhea - sudden death
Colibacillosis
34
Family Enterobacteriaceae are gram (-) short rods. True or False?
True
35
Give the mode of action of STa.
Activates guanylate cyclase in intestinal mucosal cells -> inhibition of Na and Cl absorption by brush border
36
E. coli is absent from intestines of ____ and ____.
fish and cold-blooded animals
37
Give the different lactose fermenters under Family Enterobacteriaceae.
*** CEEK 1. Citrobacter 2. Escherichia 3. Enterobacter 4. Klebsiella
38
All members of Family Enterobacteriaceae are aerobic. True or False?
True, they can also be facultatively anaerobic
39
Give the E. coli strain (that causes enteritis) with the given data: * Invade intestinal epithelial cells and replicate intracellularly * Able to proliferate more effectively in host
AIEC - adherent-invasive E. coli
40
What are the diagnostic methods for E. coli?
1. Culture and isolation 2. FAT 3. ELISA
41
Name this disease in **cattle** caused by E. coli: (includes pathogenesis + clinical signs + target host) * E. coli most important causative agent (haha this is mastitis,,, insufficient ppt infos)
Mastitis
42
Name this disease in **poultry** caused by E. coli: (includes pathogenesis + clinical signs + target host) * Other term for mushy chick disease
Omphalitis
43
E. coli is commonly found in the ____ ____ of warm-blood animals (endotherms).
lower intestines
44
Give the E. coli strain (that causes enteritis) with the given data: * Most infamous member of pathotype is O157:H7 * Causes bloody diarrhea without fever * Causes hemolytic-uremic syndrome and sudden kidney failure * Uses bacterial fimbria for attachment, moderately invasive * Possesses Shiga toxin that elicit intense inflammatory response
EHEC - enterohemorrhagic E. coli
45
Who discovered E. coli?
Theodore Escherich - German pediatrician and bacteriologist ** 1885
46
Family Enterobacteriaceae possess fimbriae or pili. True or False?
True
47
Give the E. coli strain (that causes enteritis) with the given data: * Fimbriae aggregate tissue cells * Binds to intestinal mucosa to cause watery diarrhea without fever * Non-invasive, produces hemolysins and ST enterotoxins similar to ETEC * Found only in humans
EAEC - enteroaggregative E. coli
48
This toxin is associated with destruction of gut epithelial cell microvilli --> effacing E. coli
Shiga-like toxin
49
STb has effect in cyclic GMP levels in intestinal mucosal cells. True or False?
False, no effect
50
Edema disease toxin is related to what toxin found in hemorrhagic colitis in humans?
Shiga-like toxin 2 (SLT2)
51
Give the E. coli strain (that causes enteritis) with the given data: * Only in humans * Invade enterocytes and deeper layers of mucosa of intestine * Syndrome similar to shigellosis with profuse diarrhea and high fever
EIEC - enteroinvasive E. coli
52
Name this disease in **swine** caused by E. coli: (includes pathogenesis + clinical signs + target host) * Piglets 1 to 4 days * Adhesion -> colonization -> toxin production * Profuse, pale yellow, watery diarrhea -> fatal dehydration within 18 hours -> mortality as high as 90%
Neonatal enteritis
53
These are the first of the E. coli toxins to be demonstrated.
Edema disease toxins
54
Family Enterobacteriaceae are motile with _____ flagella except ______ and ______.
peritrichous; Shigella and Klebsiella
55
What are the enterotoxins produced by E. coli?
1. Plasmid encoded heat labile LT enterotoxin 2. Heat stable ST enterotoxin 3. Edema disease toxins 4. Shiga-like toxin (SLT)
56
Name the diseases induced by E. coli in **dogs**.
1. Bacteremia - fading puppy syndrome 2. Pyometra, UTI 3. Enteritis
57
How can an animal be immunized against E. coli?
1. Passive antibodies 2. Fimbrial K88 ag 3. Bacterins to pregnant sows 4. LT/ST enterotoxins
MICRO102A
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