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BL/DD USMLE and Basics > First Aid Immunity > Flashcards

First Aid Immunity Flashcards

1
Q

Innate Immunity

A

Receptors recognize germ line encoded pathogens

Fast non specific response

Neutrophils
Macrophages
Dendritic Cells
Natural Killer cells
Complement
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2
Q

Adaptive immunity

A

V(D)J recombination
slow response
Faster with memory

T cell
B cells
Circulating Antibody

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3
Q

NK Cells

A

induce apoptosis of virally infected cells

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4
Q

B cell Function

A

Make antibodies

Opsonize bacteria
Neutralize Viruses
Activate compliment
Sensitize mast cells

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5
Q

B cell fx/ IgM, IgG

A

Activate compliment

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6
Q

B cell fx/ IgG

A

opsonize bacteria, neutralize viruses

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7
Q

B cell fx/ IgE

A

sensitize mast cells

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8
Q

T cell Fx

A

CD4 + T cells help B cell make antibody and produce cytokines

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9
Q

FAB

A

antigen binding fragment

Determines Idiotype

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10
Q

Fc

A

Constant Antibody region

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11
Q

Antibody diversity

A 
Random VJ (light)or VJD recombo
Addition of nucleotides during recombo
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12
Q

IgG characteristics

A

Main antibody
Most abundant
Crosses Placenta

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13
Q

IgG Functions

A

Delayed (2) response

  • opsonizes bacteria
  • neutralizes bacterial Toxins
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14
Q

IgA

A

Prevents attachment of bacteria and virus to mucous membrane

Found in secretions

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15
Q

IgM

A

Immediate (1) response
Fixes complement
Pentamer shape

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16
Q

IgD

A

Unclear fx

17
Q

IgE

A

binds mast cells and basophiles
allergens cause Cross links
Immediate response through mediator release (Histamine)

18
Q

Classic Pathway

A

IgG or IgM mediated
(GM makes classic cars)
Antigen-antibody complexes

19
Q

Immune response

C3b fx

A

C3b Binds Bacteria

20
Q

Immune response

C3a, C5a

A

anaphylaxis

21
Q

Live attenuated vaccine

A

Cellular response
Pro: strong immunity
Con: may become virulent

22
Q

Inactivated Vaccine

A

Humoral Immunity
Pro: stable and safer
Con: weaker response, booster shots needed

23
Q

IgG half life

A

3 weeks

24
Q

Th1 cytokine

A

Interferon gama

IFN gama

25
Q

Interferon gama function

A

Chemotaxis for monocytes

Attracts MANY macrophages/monocytes

Made by Th1

26
Q

M1 macrophages

A

Macrophages attracted be Th1

BL/DD USMLE and Basics (55 decks)

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