Immunology

Question 1

List some “physical barriers” the eye has to prevent disease

Answer 1

Blink reflex
Chemical properties of eye surface
Small size

Question 2

How do tears physically protect against disease?

Answer 2

Flushing/washout debris

Mucin layer is anti-adhesive - reduces risk of pathogen adherence to eye

Question 3

What chemical components of tears help protect against disease?

Answer 3

Lysozyme
Lactoferrin/transferrin
Complement
Antibacterial lipids
Secretory IgA

Question 4

What is the only part of the eye that has dendritic cells + lymphatic drainage?

Answer 4

Conjunctiva

Question 5

The cornea and sclera are avascular. True/False?

Answer 5

True

Question 6

How does the fact the cornea and sclera are avascular with no MALT help in protecting the eye?

Answer 6

Downregulates immune response

Question 7

What is sympathetic ophthalmia?

Answer 7

Rare bilateral granulomatous uveitis due to trauma/surgery to one eye

Question 8

What are the primary inflammatory mediators in sympathetic ophthalmia?

Answer 8

T cells

Question 9

In sympathetic ophthalmia, the injured eye is known as the excited/sympathetic eye and the fellow eye is known as the excited/sympathetic eye

Answer 9

In sympathetic ophthalmia, the injured eye is known as the excited eye and the fellow eye is known as the sympathetic eye

Question 10

Give an example of type I hypersensitivity affecting the eye

Answer 10

Allergic conjunctivitis

Question 11

Give an example of type II hypersensitivity affecting the eye

Answer 11

Ocular cicatricial pemphigoid

Question 12

Give an example of type III hypersensitivity affecting the eye

Answer 12

Corneal melt

Question 13

Give an example of type IV hypersensitivity affecting the eye

Answer 13

Corneal graft rejection