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Flashcards in Immunosuppressant Therapy Deck (9)
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1

What is an immunosuppressant drug?

drug used to prevent production of antibodies

2

What are two primary reasons that immunosuppressant drugs are used?

1. ORGAN TRANSPLANTS
2. autoimmune diseases

3

What are the secondary immunodeficiencies?

malnutrition, infection, cancer, renal disease, sarcoidosis, transplant recipients, DM

4

What is a primary immunodeficiency?

genetic, hereditary
are a group of more than 250 rare, chronic disorders in which part of the body's immune system is missing or functions improperly.

5

What is a secondary immune deficiency?

acquired!!!
disease occurs when the immune system is compromised due to an environmental facto

6

How do immunodeficiencies present clinically?

- persistant infections that occur more frequently and don't respond to Rx.
-failure to thrive
-physical and developmental disorders noted at birth (face, heart, skeleton)
-doesnt achieve or maintain physical growth and development for age

7

What is "normal healthy immune system" in a child?

average of 4-8 respiratory infections a year for first 10-12 years
mean duration is 8 days, but can last up to 2 weeks
children in day care or older siblings=more infections

8

Primary care of immunocompromised child is?

-quick aggressive treatment of infections may require rx
-no live vaccines (no household gets oral polio, other live vaccines fine)
-blood transfusion = leukocyte poor, virus free, irradiated

9

What are live virus vaccines that immunocompromised children cannot get?

rotavirus, varicells, MMR, intranasal influenza, oral polio