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Flashcards in Immunotherapies Deck (16)
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1

How can IgG be administered?

IV, IM, SC

2

What are the side effects of IVIG?

fever, chills, HA, malaise, dyspnea, uticaria, thrombosis, hemolysis, kidney injury, anaphylaxis

3

What can you premedicate a patient with before IVIG therapy to help with side effects?

Hydrate, acetaminophen or ibuprofen, histamine blocker (benadryl = diphenhydramine), possibly steroids (prednisone, methylpredinsolone, dexamthasone)

4

What pretests do you want to do before starting treatment with IVIG?

--blood borne pathogens
--relevant viral infections
--renal and liver funtion

5

HBIG
Indications
How is it administered? and w/in what time frame?

indications: post exposure prophylaxis to Hep B
administered: IM (IV available) and w/in 14 days of exposure

6

HBIG
Side effects:
CI:

SE: allergic rxn, back pain, feeling of discomfort, HA, muscle pain, nausea
CI: allergy to human immune globulin

7

Rabies Immune Globulin
Indications
How is it administered?
When do you administer vaccine?

indications: post exposure prophylaxis, pts w/ recent rabies exposure who have never had vaccine
administered: 1x dose, first around wound, rest IM into gluteal region
vaccine: same time

8

Tetanus Immune Globulin
Indications?
How is it administered?
When do you administer vaccine?

Indications: uncertain of pts history of tetanus vaccination or if they have completed their series, and has wound that is unclean or is significant
Administered: IM w/ vaccine

9

Tetanus Immune Globulin
SE
CI

SE: nephritic syndrome, angioedema, anaphylaxis, pain at injection site
CI: allergy to tetanus toxoid, OR if IM injection is CI b/c of bleeding concerns

10

Varicella-Zoster Immune Globulin (VariZIG)
Indications?
Administration?

Indications: post exposure prophylaxis for immunocompromised individuals w/o a history of immunity, newborns of mothers with varicella or zoster w/in 5 days or 48 hours of delivery
Administration: IM

11

Varicella-Zoster Immune Globulin (VariZIG)
SE

SE: chills, fatigue, rash, nausea, thrombosis, anaphylaxis, pain at injection site

12

Rho(D) immune globulin
MOA
Indications?

MO: IgG anti-D antibodies that suppress the mothers immune system from attacking Rh positive blood cells from fetal circulation
Indications: Rh neg mother with Rh positive baby

13

Rho (D) immune globulin
SE:

SE: bp, chills, fever, rash, abd pain, nausea, vommiting, joint pain, back pain, acute renal failure, decreased hemoglobin, increased bilirubin, anaphylaxis, pain at injection site, if given for ITP may also cause hemolysis

14

Rhogam
CI
Administered?

CI: hypersensitivity to immune globulins or prior sensitization to Rho(D)
Administered: 28 wks gestation, after trauma, any procedures during pregnancy, suspicion of hemorrhage, miscariage or abortion
72 hours after delivery if baby is Rh positive

15

Rhogam -- what are other uses?

ITP
incompatible blood transfusions

16

Anti-IgE therapy
Xolair-- recombinant monoclonal antibody
What is it used for?
Administration?
How long until notice effects?

-Used for treatment of moderate to severe persistent asthma after failure of high dose inhaled steroids
-serum IgE = 30-700Iu/mL
Admin: weight based, sub q injections every 2-4 wks
Effects: up to 12 weeks, long term therapy