Interstitial Lung Disease Flashcards Preview

ESA 3 - Respiratory System > Interstitial Lung Disease > Flashcards

Flashcards in Interstitial Lung Disease Deck (159)
Loading flashcards...
1

What is the interstitial space? 

A potential space between alveolar cells and the capillary basement membrane, which is only apparent in disease states

2

What may the interstitial space contain in disease states? 

Fibrous tissue, cells, or fluid

3

What is interstitial lung disease? 

A group of diseases with a variety of causes, that all have similar pathological effects and clinical features

4

What is the pathophysiology of interstitial lung disease? 

The development of fibrous tissue in the intersticium, producing a restrictive ventilatory defect 

5

Why does the development of fibrous tissue in the intersticium produce a restrictive ventilatory defect? 

Because it makes the lungs less compliant 

6

Is airway resistance increased in interstitial lung disease? 

No

7

How can the FEV1/FVC ratio be kept >70% in interstitial lung disease?

Due to increased radial traction on the airway keeping the airway open 

8

What impairs gas exchange in interstitial lung disease? 

Lengthening of the diffusion path

9

What is selectively affected in interstitial lung disease? 

Oxygen uptake

10

Why is oxygen uptake selectively affected in interstitial lung disease? 

As CO2 diffuses much more readily 

11

What are the symptoms of interstitial lung disease? 

  • Shortness of breath 
  • Reduced exercise tolerance 
  • Dry cough

 

12

What are the signs of interstitial lung disease? 

  • Tachypnoea
  • Tachycardia 
  • Reduced chest movement bilaterally 
  • Coarse crackles 

 

13

What signs may be present in interstitial lung disease? 

  • Cyansosis
  • Signs of right heart failure 

 

14

When is clubbing seen in interstitial lung disease? 

Cryptogenic fibrosing alveolitis 

 

 

15

What are the categories of causes of interstitial lung disease? 

  • Occupational 
  • Treatment related
  • Connective tissue disease 
  • Immunological 
  • Idiopathic

 

16

What are the occupational causes of interstitial lung disease? 

  • Abestosis
  • Silicosis 
  • Coal workers pneumoconiosis 

 

17

What are the treatment related causes of interstitial lung disease? 

  • Radiation 
  • Methotrexate
  • Nitrofurantoin 
  • Amiodarone
  • Chemotherapy 

 

18

What connective tissue diseases can cause interstitial lung disease? 

  • Rheumatoid arthritis 
  • SLE
  • Polymyositis 
  • Schleroderma 
  • Sjorgen's 

 

19

What are the immunological causes of interstitial lung disease? 

  • Sarcoidosis 
  • Hypersensitivity pneumonitis (EAA) 

 

20

What are the idiopathic causes of interstitial lung disease? 

  • CFA/IPF
  • UIP/NSIP
  • DIP
  • LIP
  • RB-ILD
  • COP (BOOP)

 

 


CFA- cryptogenic fibrosing alveolitis 
IPF- idiopathic pulmonary fibrosis
UIP- usual interstitial pneumonia 
NSIP- non-specific interstial pnuemonia 
DIP- desquamative interstial pneumonia 
LIP- lymphoid interstitial pnuemonia 
RBILD- respiratory bronchiolitis interstiial lung disease
COP- crytogenic organising pneumonia 
BOOP- bronchiolitis oblitirans organising pneuomnia

 

for princess elliot 

21

What is fibrosing alveolitis? 

A progressive inflammatory condition of an unknown cause 

22

How common is fibrosing alveolitis? 

Relatively rare, 3-5 cases per 100,000

23

How does the incidence of fibrosing alveolitis differ between the sexes? 

It is two times more common in males 

24

What are the histological features of fibrosing alveolitis? 

Increased activated alveolar macrophages 

25

What is the effect of increased activated alveolar macrophages in fibrosing alveolitis? 

  • Attract neutrophils and eosinophils
  • Local lung damage
  • Tissue destruction and fibrosis

 

26

Why do increased alveolar macrophages lead to local lung damage? 

Due to ROS and proteases

27

What do patients report with fibrosing alveolitis? 

Progressive shortness of breath on exercise, often with non-productive cough

28

Do patients with fibrosing alveolitis have finger clubbing? 

Most do 

29

What does the chest x-ray show in patients with fibrosing alveolitis? 

Small lungs with micro-nodular shadowing predominating in the lower lobes, with ragged heart borders

30

When can fibrosing alveolitis be restrained? 

In the early stages, less effective once fibrosis has developed