NCE part 2 Flashcards Preview

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Flashcards in NCE part 2 Deck (125)
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1

Type A nerve fibers - describe their myelination

heavy

2

Type B nerve fiber describe their myelination

light myelination

3

type c nerve fibers- describe their myelination

no myelination

4

what is type A alpha nerve fiber responsible for

proprioception
motor

5

what is type a gamma nerve fiber responsible for

muscle spindles

gaMMa - "M's for Muscles"

6

type a delta nerve fiber is responsible for

pain
temperature

"DELToid Pain"

7

type a beta nerve fibers is responsible for

touch
pressure

"make a BET!" -->and slam your hand down!!

8

A- gamma nerve is responsible for

Muscle Spindles - think muscle tone

9

A-delta nerve fibers are responsible for :

Pain and Temperature

10

Which nerve fibers are preganglionic autonomic ?

Type B nerve fibers

11

C fibers are responsible for 1) _____via the dorsal root and are _______

Pain via dorsal root

and are

Postganglionic Sympathetic fibers

12

Which fiber is responsible for pain via the dorsal root ?

C fibers

13

Those are Postganglionic sympathetic nerve fibers .

C fibers

14

#1 cause of methemoglobinemia

Benzocaine

15

Describe Zero Order kinetics . What are drug examples ?

1)Constant AMOUNT of drug eliminated per unit of time
2) Metabolic pathways are saturated
Drug ex: Salicylate, theophylline , phenytoin , and ethanol .

16

What is First Order kinetics? Which examples of drugs ?

1) Constant FRACTION of drug eliminated per unit of time
2) Elimination proportionate to amount of drug in the body

Drug ex: Most drugs are first order kinetics -- SUX

17

Volume distribution

Amount of drug in body divided by amount in the in the blood
drug in body/drug in blood

Large Vd= lipid solubility
Small Vd= lipid insolubility

18

What is clearance ?

Complete drug removal from a volume of plasma per unit of time.

19

Elimination half time is : Time to eliminate 100% of drug from the plasma . True or False

False !
50% ( half)

20

4 half lives =

94% complete

21

Context - Sensitive Half-time :

Time needed for the plasma drug concentration to decrease by 50% (or any other percentage ) AFTER DISCONTINUING a continuous infusion with a specific duration .

Context = infusion duration

It considers combined effect of : distribution + metabolism+ duration of a continuous IV administration on the drug’s pharmacokinetics

22

A drug that is eliminated by first order kinetics has a half-life of elimination of 6 hours. How much drug remains after 18 hours if 10mg is administered

1.25mg

23

160 mg of drug is administered and 20 mg remains 30 hours later. How much drug is lost in the next 20 hours if the drug is eliminated by first order kinetics:

15 mg

at third 1/2Life = 20mg
4th = 20/2 = 10mg
5th = 10/2 = 5mg

in the next 20 hours you add the 4th and 5th 1/2 lives b/c they're each 10 hours = this gives you 15mg of drug lost in the "next 20 hours"

24

mu2

Analgesia (Spinal)

Respiratory depression(decrease sensitivity of resp. center to CO2)

Addiction

Constipation (marked) decrease motility and tone of GI muscles
increase CSF pressure (cerebral edema) C/I in head injury

25

kappa

Analgesia (Spinal & Supraspinal)

Dysphoria

Low abuse
Potential

Miosis
Diuresis

26

delta

Analgesia (Spinal & Supraspinal)

Respiratory depression

Physical dependence

Constipation (mild)

27

what type of compound is neuromuscular blocker

quaternary ammonium compound

28

all neuromuscular blockers are structurally related to

acetylcholine

29

T?F
majority of NMBD are synthetic alkaloids

true

30

NMBD classified by chemical class:

Steroidal
Benzylisoquinoinium
Other