Spring 2020 - pharm exam 3 Flashcards Preview

Fall'20 Pharmacology III > Spring 2020 - pharm exam 3 > Flashcards

Flashcards in Spring 2020 - pharm exam 3 Deck (77)
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1

CCB may increase the plasma concentration of:

Digoxin

2

Digoxin plasma concentration may be increased by:

CCB's

3

Which effects of propranolol are most important?

-Decreased HR
-Decreased contractility

4

If a patient is saying their ears are ringing; what might you anticipate their plasma concentration of Lidocaine to be?

5MCG/ml

5

what medication would you avoid with Raynaud's Syndrome?

Propranolol

6

What drug decreases the plasma CLEARANCE of lidocaine and bupivacaine?

Propranolol

7

Q: Which of the following is Ture:

Answers are: (finish them)
-Epinephrine is...
-Phenylephrine is...
-Dobutamine is...

-Epi (Direct general agonist)
-Neo (pure alpha agonist), A1>A2)
-Dobutamine (Beta 1 > beta 2)

8

Drug with greatest potential to produce ventricular arrhythmias:

Dopamine

9

Which is associated with active metabolites? (beta blockers)

Propranolol

10

LA prevent the transmission of nerve impulses by inhibiting what specific voltage gated channels?

sodium

11

Large IV bolus of Precedex leads to:

HTN
Bradycardia

12

What LA has the greatest protein binding?

Levobupivacaine

13

Is tetany a SE of CCB?

No

14

What are SE of CCBs?

hypotension
H/A
Flushing
Edema
Constipation?

15

What drug can cause reflex bradycardia?

Phenylephrine

16

What is the regional dose of lidocaine with epinephrine?

7mg/kg

17

Name two things that are true regarding Diltiazem?

1. First line tx for SVT
2. Minimal vasodilating properties; intermediate b/w verapamil and dihydrophyridines

1.) Diltiazem has minimal cardiodepressant effects and Is unlikely to interact with beta blocking drugs
-tx WPW

18

Ephedrine indirectly or directly stimulates.... (receptors)

indirectly
alpha and beta

19

What amide LA undergoes the slowest metabolism:

bupivacaine

20

List CCB least to greatest for AV/SA node effect & Vasodilation properties

verapamil , diltiazem, dihydrophyridines (nicardipine, etc)

21

List the amides in order of slowest to fastest metabolism:

fastest -to slowest : Prilocaine, Lido/mepiv, etio, bupivacaine=ropivacaine

SLOWEST
-ropivacaine
-bupivacaine
-mepivacaine
-Lidocaine
-Prilocaine
FASTEST

22

Which of the sympatholytics can be administered orally?

Ephedrine

23

Which of the following has very little beta stimulation?

phenylephrine

*epi, norepi, ephedrine and dobutamine definitely do

24

Name a rapid onset selective beta 1 antagonist:

Esmolol

25

Which LA is 35 times more lipid soluble and has a potency and DOA 3-4 times that of mepivacaine:

bupivicaine

26

Principle difference in pharmacokinetecs b/w all the beta blockers is:

elimination Half-time

27

Dobutamine leads to an increase in

cAMP

28

Clearance comparison between Ropivacaine and bupivacaine:

Bupivacaine half time is LONGER

*ropivacaine lipid solubility is less than bupivicaine; and has a shorter half time

29

what pharmacological effects of propranolol are most important? (2)

-decreased HR
-decreased contractility

30

Protein binding of Beta Blockers from greatest to least:

Propranolol > Metoprolol > atenolol

** add
"PENAMA"
Propranolol
esmolol
nadolol
acebutolol
Metoprolol
Atenolol