Flashcards in Spring 2020 - pharm exam 3 Deck (77)
CCB may increase the plasma concentration of:
Digoxin plasma concentration may be increased by:
Which effects of propranolol are most important?
If a patient is saying their ears are ringing; what might you anticipate their plasma concentration of Lidocaine to be?
what medication would you avoid with Raynaud's Syndrome?
What drug decreases the plasma CLEARANCE of lidocaine and bupivacaine?
Q: Which of the following is Ture:
Answers are: (finish them)
-Epi (Direct general agonist)
-Neo (pure alpha agonist), A1>A2)
-Dobutamine (Beta 1 > beta 2)
Drug with greatest potential to produce ventricular arrhythmias:
Which is associated with active metabolites? (beta blockers)
LA prevent the transmission of nerve impulses by inhibiting what specific voltage gated channels?
Large IV bolus of Precedex leads to:
What LA has the greatest protein binding?
Is tetany a SE of CCB?
What are SE of CCBs?
What drug can cause reflex bradycardia?
What is the regional dose of lidocaine with epinephrine?
Name two things that are true regarding Diltiazem?
1. First line tx for SVT
2. Minimal vasodilating properties; intermediate b/w verapamil and dihydrophyridines
1.) Diltiazem has minimal cardiodepressant effects and Is unlikely to interact with beta blocking drugs
Ephedrine indirectly or directly stimulates.... (receptors)
alpha and beta
What amide LA undergoes the slowest metabolism:
List CCB least to greatest for AV/SA node effect & Vasodilation properties
verapamil , diltiazem, dihydrophyridines (nicardipine, etc)
List the amides in order of slowest to fastest metabolism:
fastest -to slowest : Prilocaine, Lido/mepiv, etio, bupivacaine=ropivacaine
Which of the sympatholytics can be administered orally?
Which of the following has very little beta stimulation?
*epi, norepi, ephedrine and dobutamine definitely do
Name a rapid onset selective beta 1 antagonist:
Which LA is 35 times more lipid soluble and has a potency and DOA 3-4 times that of mepivacaine:
Principle difference in pharmacokinetecs b/w all the beta blockers is:
Dobutamine leads to an increase in
Clearance comparison between Ropivacaine and bupivacaine:
Bupivacaine half time is LONGER
*ropivacaine lipid solubility is less than bupivicaine; and has a shorter half time
what pharmacological effects of propranolol are most important? (2)