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Flashcards in Pharm 4 Deck (30)
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2
Q

GnRH agonist used for infertility - pulsatile usage

Different types of CA - steady usage

A

Leuprolide

3
Q

GnRH antagonist with more immediate effects, used for infertility

A

Ganirelix

4
Q

T3 compound less widely used

A

Cytomel

5
Q

Anti-thyroid drugs

A

Thioamides, iodides, radioactive iodine, and ipodate

6
Q

Thioamide agents used in hyperthyroidism

A

Methimazole and propylthiouracil (PTU)

7
Q

Can be effective for short term therapy of thyroid storm, but after several weeks of therapy causes an exacerbation of hyperthyroidism

A

Iodide salts

8
Q

Permanently cures thyrotoxicosis, patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy

A

Radioactive iodine

9
Q

Radio contrast media that inhibits the conversion of T4 to T3

A

Ipodate

10
Q

Block cardiac adverse effects of thyrotoxicosis such as tachycardia, inhibits the conversion of T4 to T3

A

Beta-blockers such as propranolol

11
Q

3 zones of adrenal cortex and their products

A

“GFR”
Glomerulosa (mineralocorticoids)
Fasciculata (glucocorticoid=GC)
Reticularis (adrenal androgens)

12
Q

Pneumonic for 3 zones of adrenal cortex

A

GFR

13
Q

Used for Addison’s disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)

A

Glucocorticoids

14
Q

Short acting GC’s

A

Cortisone and hydrocortisone (equivalent to cortisol)

15
Q

Intermediate acting GC’s

A

Prednisone, methylprednisolone, prednisolone, and triamcinolone

16
Q

Long acting GC’s

A

Betamethasone, dexamethasone, and paramethasone

17
Q

Mineralocorticoids

A

Fludrocortisone and deoxycorticosterone

18
Q

Period of time of therapy after which GC therapy will need to be tapered

A

5-7 days

19
Q

Used for Cushing’s syndrome (increased corticosteroid) and sometimes for adrenal function test

A

Metyrapone

20
Q

Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis

A

Aminoglutethimide

21
Q

Antifungal agent used for inhibition of all gonadal and adrenal steroids

A

Ketoconazole

22
Q

Antiprogestin used as potent antagonist of GC receptor

A

Mifepristone

23
Q

Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss

A

Estrogen

24
Q

Antiestrogen drugs used for fertility and breast cancer respectively

A

Clomiphene and tamoxifen

25
Q

Common SE of tamoxifen and raloxifene

A

Hot flashes

26
Q

Estrogen mostly used in oral contraceptives (OC)

A

Ethinyl estradiol and mestranol

27
Q

Anti-progesterone used as abortifacient

A

Mifepristone (RU-486)

28
Q

Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)

A

Combination oral contraceptives (OC)

29
Q

Oral contraceptive available in a transdermal patch

A

Ortho-Evra

30
Q

5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness

A

Finasteride (Proscar and Propecia respectively)

31
Q

Anabolic steroid that has potential for abuse

A

Nandrolone and stanozolol