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Flashcards in Pharmacology Week 2 Deck (100)
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1

Classes of Treatment for IBD & IBS

Aminosalicylates
Corticosteroids
Antibiotics
Immunosuppressive agents
Biological agents

2

Characteristics to determine which treatment should be used

Severity of disease
UC
Crohn's lesions locations
Exacerbations vs. maintenance

3

Drugs used for Treatment of IBD

Aminosalicylates
Corticosteroids
Immunosuppresive agents
IV cyclosporine
Antibiotics
Immune modifiers

4

When do you use aminosalicylates in the treatment of IBD?

Mild to moderate UC & CD exacerbations
Maintenance of remission

5

When do you use corticosteroids in the treatment of IBD?

Treatment of UC & CD exacerbations

6

When do you use immunosuppressive meds in the treatment of IBD?

Maintain remission

7

When do you use IV cyclosporine in the treatment of IBD?

Severe active refractory UC

8

When do you use antibiotics in the treatment of IBD?

Acute exacerbations
Maintenance of remission

9

When do you use immune modifiers in the treatment of IBD?

Maintain remission in steroid refractory UC & CD

10

Examples of Aminosalicylates

Sulfasalazine (Azulfidine)
Mesalamine (Asacol, Pentasa)
Olsalazine (Dipentum)
Basalazide (Colazal)

11

Clinical Uses for Aminosalicylates

Induce/maintain remission in UC

12

Routes of Administration of Aminosalicylates

PO
Enema
Suppository

13

Suflasalazine (Asulfidine)

Preg. B
Converted to mesalamine in the proximal colon

14

Contraindications of Sulfasalazine (Asulfidine)

Sulfa allergy

15

Mesalamine (Asacol, Pentasa)

Preg B
Works like a topical agent due to being poorly absorbed

16

Drug Release of Asacol Oral Tablets

Distal ileum & colon

17

Drug Release of Pentasa Oral Capsules

Proximal small intestine and throughout the colon

18

Routes of Administration of Melalamine

Oral tablets (Asacol)
Oral capsules (Pentasa)
Enema
Rectal suppositories

19

Where can a mesalamine enema reach?

Distal/sigmoid colon

20

When are melamine rectal suppositories primarily used?

UC proctitis

21

Why are the aminosalicylates banalized (Colazal) and olsalazine (Dipentum) not used frequently?

Increased cost
No extra efficacy

22

MOA of Aminosalicylates

Blocks prostaglandin production
Interferes with production of inflammatory cytokines
Inhibit NK cells, lymphocytes & macrophages

23

Contraindications of Aminosalicylates

Aspirin/salicylate allergy
G6PD deficiency

24

SE of Sulfasalazine

N/V
Photosensitivity
Oligospermia
Skin discoloration
Decreased folate levels
SJS
Crystalluria
Pancreatitis
Hepatitis
Bone marrow suppression

25

Labs to monitor with Sulfasalazine

CBC with diff
LFTs

26

SE of Mesalamine

Headache
Malaise
Abdominal pain
Diarrhea

27

SE of Olsalazine

Headache
Malaise
Abdominal pain
Severe secretory diarrhea

28

SE of Balsalazide

Headache
Malaise
Abdominal Pain
Diarrhea
Staining of teeth (capsule opened & sprinkled on food)

29

Monitoring of Mesalamine

Renal function
CBC
Hepatic function

30

Short Term SE of Steroids

Hyperglycemia
Increased appetite
Insomnia
Anxiety
Tremors
Increased fluid retention
Increased BP