Flashcards in Skeletal Muscle Paralytics - Trachte Deck (14):
What receotrs and neurotransmitter mediates skeletal muscle contraction?
What can you use anticholinesterases for?
Treating myasthenia gravis
What toxin blocks nicotinic receptors?
alpha-bungarotoxin - from snakes
What 3 drugs block acetylcholine degradation?
Neostmine, pyridostigmine, edrophonium
What toxin blocks ACh release?
What toxins bock nicotinic receptors?
What drug blocks ca-induced Ca release?
What drug is used to diagnose myasthenia gravis
What is the toxicity of acetylcholinesterase?
sweating, lacrimation, urination, diarrhea, Gi, emesis
Competetive blocker of nicotinic receptors?
(block Na influx, depolarization, contraction)
Drug that depolarizes the end plate of the muscle and leads to chronic Na infux (then fasciculations and flaccid paralysis)
Toxic effects of nicotinic receptor antagonists?
Apnea, histamine release, cardiovascular collapse
Malignant hyperthermia caused by halothane and succinylcholine (1 in 15,000)
-treatment is dantrolene (dantrium) - inhibits Ca2+ release from sarcoplasmic reticulum by blocking the Ryanodine receptor (Calcium-induced calcium release)
Advantage of Mivacurium over Tubocurarine?
It is shorter acting, if that's what you want