Skeletal Muscle Paralytics - Trachte Flashcards Preview

Skin and Musculoskeletal - Week 4 > Skeletal Muscle Paralytics - Trachte > Flashcards

Flashcards in Skeletal Muscle Paralytics - Trachte Deck (14):
1

What receotrs and neurotransmitter mediates skeletal muscle contraction?

Nicotinic receptors

Acetylcholine

2

What can you use anticholinesterases for?

Treating myasthenia gravis

Treating poisoning

3

What toxin blocks nicotinic receptors?

alpha-bungarotoxin - from snakes

4


What 3 drugs block acetylcholine degradation?



Neostmine, pyridostigmine, edrophonium


5

What toxin blocks ACh release?

Botulinum toxin

6

What toxins bock nicotinic receptors?

d-turbocurarine
Mivacurium

7

What drug blocks ca-induced Ca release?

Dantrolene

8

What drug is used to diagnose myasthenia gravis

edrophonium

9

What is the toxicity of acetylcholinesterase?

SLUDGE
sweating, lacrimation, urination, diarrhea, Gi, emesis

10

Competetive blocker of nicotinic receptors?

turbocurarine

(block Na influx, depolarization, contraction)

11

Drug that depolarizes the end plate of the muscle and leads to chronic Na infux (then fasciculations and flaccid paralysis)

succinylcholine

12

Toxic effects of nicotinic receptor antagonists?

Apnea, histamine release, cardiovascular collapse

Malignant hyperthermia caused by halothane and succinylcholine (1 in 15,000)
-treatment is dantrolene (dantrium) - inhibits Ca2+ release from sarcoplasmic reticulum by blocking the Ryanodine receptor (Calcium-induced calcium release)

13

Advantage of Mivacurium over Tubocurarine?

It is shorter acting, if that's what you want

14

Why should you check to see if someone has butyrlcholinesterase before giving them succinylchoine?

Why avoid it in burn victims?

That is what breaks it down, if they dont have enough of the enzyme then the drug will last WAY too long.

Burned muscle increases the concentration of nicotinic receptors resulting in excessive potassium release in response to succinylcholine