Stroke

Question 1

goals of treatment ICH

Answer 1

contain and limit bleeding
remove blood
manage complications (ICP, decrease cerebral perfusion)
control causative factor

Question 2

contraindicated drugs ICH

Answer 2

thrombolytics, anticoagulants, warfarin, antiplatelet drugs

Question 3

goals of treatment SAH

Answer 3

quickly identify cause and prevent rebleeding

prevent brain damage

Question 4

this is a dihydropyridine CCB that reduces incidence and severity of ischemic defects that can occur after a SAH

Answer 4

nimodipine

Question 5

this drug is metabolized by CYP450 3A4 enzymes

Answer 5

nimodipine

Question 6

causes of ischemic stroke

Answer 6

thrombosis
embolism
systemic hypoperfusion

Question 7

rule this out prior to initiation of therapy for ischemic stroke

Answer 7

hemorrhagic stroke

Question 8

only FDA approved therapy for treatment of acute ischemic stroke

Answer 8

rtPA, alteplase

Question 9

onset of symptoms to administration of this drug must be less than 3 hours

Answer 9

rtPA

Question 10

contraindications include prior ICH, sustained BP >185/110, low platelets, low HCT, recent major surgery, GI bleed, MI, stroke, head trauma, coma

Answer 10

rtPA

Question 11

BP should be stabilized at <180/105 and maintained before treating with

Answer 11

rtPA

Question 12

this drug is found to increase morbidity and mortality secondary to ICH

Answer 12

streptokinase

Question 13

goals of therapy ischemic stroke

Answer 13

reduce progression
reduce risk of recurrent thromboembolism
prevent DVT/PE

Question 14

only antiplatelet agent evaluated for the treatment of acute ischemic stroke

Answer 14

aspirin

Question 15

DVT/PE prophylaxis acute ischemic stroke

Answer 15

low dose SQ heparin or LMWH

Question 16

DVT/PE prophylaxis ICH

Answer 16

intermittent pneumatic compression- low dose SQ heparin

Question 17

drug classes for recurrent stroke prevention

Answer 17

thiazides

ACEI