4: Alcohol and the CNS Flashcards Preview

CLASP: Alcohol 2017/18 > 4: Alcohol and the CNS > Flashcards

Flashcards in 4: Alcohol and the CNS Deck (24)
Loading flashcards...
1

Alcohol is (clear / coloured) with a (pleasant / unpleasant) odour.

clear

pleasant

2

Alcohol is aliphatic - what does this mean?

Forms chains, not aromatic rings

3

Is alcohol soluble?

Yeah

4

What is the functional group found in alcohol?

Hydroxyl

-OH

5

What kind of bonding does the hydroxyl group of ethanol give rise to?

Hydrogen bonding

6

Does ethanol have any isomers?

No

7

Ethanol is well absorbed by the ___ route.

oral

8

20% of ethanol absorption occurs in the ___.

The other 80% occurs in the ___ ___.

stomach

small intestine

9

Ethanol has the capacity to produce which effect?

General anaesthesia

10

As the number of carbons in an alcohol molecule increases, the greater their ability to act as a ___ ___.

What is this rule called?

general anaesthetic

Meyer-Overton Rule

11

Are alcohols used as a general anaesthetic in humans?

No

jesus christ

12

What is the cut-off point for the general anaesthetic effects of n-alcohols?

Hexanol (6) - pentanol (8)

Then it starts to decrease

13

What effects does alcohol have in mice?

Loss of righting reflex (can't adjust to changes from upright)

Ataxia (difficulty walking)

14

Ethanol affects which two types of neurotransmitter in the CNS?

Excitatory

Inhibitory

15

Which excitatory neurotransmitter does ethanol affect?

Glutamate

16

Which inhibitory neurotransmitters are affected by ethanol?

GABA

Glycine

17

Excitatory neurotransmitters such as ___ allow the entry of ___ ions.

What effect does this have on the membrane potential?

glutamate , sodium

depolarisation

18

Inhibitory neurotransmitters such as ___ or ___ allow the entry of ___ ions.

What effect does this have on the membrane potential?

GABA or glycine , chloride

hyperpolarisation

19

Glutamate triggers an ____ action potential.

excitatory

20

GABA and glycine trigger an ____ action potential.

inhibitory

21

Ethanol's effects on excitatory and inhibitory neurotransmitters is thought to cause one of its main effects, which is ___ ___.

CNS depression

22

Lots of proteins have cavities specifically "designed" for the binding of ___.

ethanol

23

What is the drink-drive limit in BAC?

0.05g / 100ml blood

i.e 0.05

24

(See BAC chart for effects on behaviour at different blood alcohol concentrations.)