READ ME / 1: Acute alcohol intoxication Flashcards Preview

CLASP: Alcohol 2017/18 > READ ME / 1: Acute alcohol intoxication > Flashcards

Flashcards in READ ME / 1: Acute alcohol intoxication Deck (60)
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1

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2

The questions are written using the official Dundee lectures, so you might find it useful to have them open in the background in case you get stuck.

3

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4

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5

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6

Alcohol is a ___.

drug

7

What is the functional group found in alcohol molecules?

OH

hydroxyl

8

Methanol is ___ and (should / shouldn't) be consumed.

toxic

shouldn't

9

Where may methanol occasionally be found?

Home brew alcohol

10

What is methanol metabolised into?

Formaldehyde (fixes tissue)

Formic acid (dissolves you)

11

What is the main symptom of methanol poisoning?

Blindness

12

How is methanol poisoning treated?

Ethanol +/- dialysis

13

What enzyme metabolises both methanol and ethanol?

Alcohol dehydrogenase

14

By which principle does drinking ethanol help with methanol poisoning?

Competitive inhibition by ethanol

i.e it competes with methanol for the alcohol dehydrogenase enzymes

15

Which group of women are advised not to drink alcohol?

Pregnant women

16

Why does drinking on a full stomach reduce the rate of alcohol absorption?

Reduced gastric emptying

So more alcohol is metabolised in the stomach instead of being absorbed into the bloodstream

17

What is the recommended weekly intake of alcohol for men and women?

14 units

18

If a patient is consuming alcohol regularly over a week, they should have several ___ days.

rest

19

Alcohol is soluble in ___.

water

20

Alcohol absorption in the stomach is ___.

Where in the GI tract is mainly responsible for alcohol absorption?

minimal

Small bowel

21

Which drugs increase the rate of gastric emptying and therefore increase the rate at which alcohol is absorbed in the small bowel?

Antihistamines (inc. rate of emptying)

Metoclopramide (for gastroparesis, inc. rate of emptying)

Domperidone ("")

22

Drinking high concentrations of alcohol will result in it being absorbed (more quickly / more slowly).

Why?

more slowly

Irritates gastric mucosa > delays empyting

23

What drinks are aerated and tend to be absorbed quickly?

Champagne, prosecco etc.

24

Do women have a lower tolerance for alcohol than men?

Yes

25

Why do females have a lower tolerance for alcohol than men?

Males have a leaner body mass on average

More water > greater volume for dilution

Females have lower alcohol dehydrogenase activity as well

26

Which enzyme, which metabolises alcohol, do females have less of compared to men?

Alcohol dehydrogenase

27

Where is most alcohol metabolised?

Liver

28

Apart from the liver, where else is alcohol metabolised?

Pancreas

Brain

29

Apart from in the urine, where else is alcohol excreted?

Breath

Sweat

Stool

30

Alcohol is removed from the blood at 15mg/100ml/hour - how many units is this roughly equivalent to?

1 unit per hour