Goodpasture Disease Flashcards Preview

Nelson - Nephrology > Goodpasture Disease > Flashcards

Flashcards in Goodpasture Disease Deck (8)
Loading flashcards...
1
Q

Disease characterized by pulmonary hemorrhage and GN

A

Goodpasture disease

2
Q

Pathogenesis of Goodpasture disease

A

Abs directed against certain epistopes of Type IV collagen (alveolar basement membrane and GBM)

3
Q

Kidney biopsy in most patients with Goodpasture disease shows

A

CGN (crescentic GN)

4
Q

IF in Goodpasture disease shows

A

Continuous linear deposition of IgG along the GBM

5
Q

Patients with Goodpasture disease usually present with

A

Hemoptysis

6
Q

Serologic picture in Goodpasture disease

A

(+) Anti-GBM antibody and normal C3, occasionally anineutrophilic cytoplasmic antibody

7
Q

Untreated, the prognosis of Goodpasture disease is

A

Poor

8
Q

Treatment for Goodpasture disease

A

High-dose IV methylpred, cyclo, and plasmapheresis