Flashcards in Goodpasture Disease Deck (8)
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1
Q
Disease characterized by pulmonary hemorrhage and GN
A
Goodpasture disease
2
Q
Pathogenesis of Goodpasture disease
A
Abs directed against certain epistopes of Type IV collagen (alveolar basement membrane and GBM)
3
Q
Kidney biopsy in most patients with Goodpasture disease shows
A
CGN (crescentic GN)
4
Q
IF in Goodpasture disease shows
A
Continuous linear deposition of IgG along the GBM
5
Q
Patients with Goodpasture disease usually present with
A
Hemoptysis
6
Q
Serologic picture in Goodpasture disease
A
(+) Anti-GBM antibody and normal C3, occasionally anineutrophilic cytoplasmic antibody
7
Q
Untreated, the prognosis of Goodpasture disease is
A
Poor
8
Q
Treatment for Goodpasture disease
A
High-dose IV methylpred, cyclo, and plasmapheresis