Goodpasture Disease Flashcards Preview

Nelson - Nephrology > Goodpasture Disease > Flashcards

Flashcards in Goodpasture Disease Deck (8):
1

Disease characterized by pulmonary hemorrhage and GN

Goodpasture disease

2

Pathogenesis of Goodpasture disease

Abs directed against certain epistopes of Type IV collagen (alveolar basement membrane and GBM)

3

Kidney biopsy in most patients with Goodpasture disease shows

CGN (crescentic GN)

4

IF in Goodpasture disease shows

Continuous linear deposition of IgG along the GBM

5

Patients with Goodpasture disease usually present with

Hemoptysis

6

Serologic picture in Goodpasture disease

(+) Anti-GBM antibody and normal C3, occasionally anineutrophilic cytoplasmic antibody

7

Untreated, the prognosis of Goodpasture disease is

Poor

8

Treatment for Goodpasture disease

High-dose IV methylpred, cyclo, and plasmapheresis