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Flashcards in Heme/oncology Deck (165)
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What population is most likely to be diagnosed with osteogenic sarcoma? How do they present ?

Black teenager who presents with bone pain

1

What diagnosis should you consider in a teenager with leg pain who is going through a growth spurt?

Osteogenic sarcoma

2

What is the treatment of osteogenic sarcoma ? (2)

Amputation or limb salvage
Chemotherapy

3

What is the most common site of metastasis from osteogenic sarcoma?

Lung

4

What type of bone sarcoma presents with a soft tissue component?

Ewing sarcoma

5

What is the most common type of solid tumor in children?

Brain tumors

6

What diagnosis presents with left leg pain that is worse at night but relieved with ibuprofen?

Osteoid osteoma

7

What is the diagnosis of a femur with central radiolucent area surrounded by thick sclerotic bone?

Osteoid osteoma

8

What are 3 poor prognostic signs of ALL?

Age <2
WBC > 50
T cell precursor

9

Which sanctuary sites of ALL are most resistant to therapy and common sites of relapse?

CNS and testes

10

What is the correct first step in diagnosis in a child with unexplained lymphadenopathy and cough?

Chest X-ray

11

What diagnosis should you consider in a teenager who presents with non tender cervical lymph node and high WBCs?

Hodgkin lymphoma

12

What cells would you expect to find on lymph node biopsy in a patient with Hodgkin lymphoma ?

Reed sternberg

13

What is the first course of action in a patient with fever who has had splenectomy?

Sepsis workup

14

What is the difference between lymphoblastic and nonlymphoblastic non Hodgkin lymphoma?

Lymphoblastic is t. Cell origin and non lymphoblastic is b. Cell origin

15

Where are the 3 most common sites of mass secondary to non Hodgkin lymphoma ?

Head, neck, abdomen

16

What 3 tumors should you consider in a child with non tender abdominal mass?

Wilms
Neuroblastoma
Non Hodgkin lymphoma

17

What is the difference in bone marrow findings between leukemia and lymphoma?

Leukemia has >25% blasts
Lymphomas has <25% blasts

18

How is langerhans cell histiocytosis diagnosed?

Skin biopsy and electron microscopy

19

How is langerhans cell histiocytosis treated ? (3)

Surgery, steroids or chemo

20

What diagnosis should you consider in a patient with a lytic skull lesion and seborrheic rash?

Langerhans cell histiocytosis

21

What urinary problems are associated with langerhans cell histiocytosis?

Diabetes insipidus and excessive urination

22

Where is the most common place for presentation of neuroblastoma?

Adrenal gland

23

What is the prognosis of neuroblastoma?

Survival 95% if occurs prior to 1 year - poor prognosis of older than 1

24

How is neuroblastoma diagnosed?

Tumor biopsy or high urine VMA/HMA plus bone marrow tumor

25

What is the best imaging study to find neuroblastoma?

CT with contrast

26

What are 3 common lab abnormalities associated with neuroblastoma ?

Pancytopenia
Elevated ferritin
Elevated LDH

27

What is the most Likely cause of HTN in a patient with neuroblastoma?

Renal artery compression

28

What diagnosis should you consider in a patient with non tender abdominal mass, HTN and diarrhea ?

Neuroblastoma

29

What syndrome can occur from mediastinal tumor in a patient with neuroblastoma ?

Horner syndrome (compression of recurrent laryngeal nerve)