Flashcards in Heme/oncology Deck (165)
What population is most likely to be diagnosed with osteogenic sarcoma? How do they present ?
Black teenager who presents with bone pain
What diagnosis should you consider in a teenager with leg pain who is going through a growth spurt?
What is the treatment of osteogenic sarcoma ? (2)
Amputation or limb salvage
What is the most common site of metastasis from osteogenic sarcoma?
What type of bone sarcoma presents with a soft tissue component?
What is the most common type of solid tumor in children?
What diagnosis presents with left leg pain that is worse at night but relieved with ibuprofen?
What is the diagnosis of a femur with central radiolucent area surrounded by thick sclerotic bone?
What are 3 poor prognostic signs of ALL?
WBC > 50
T cell precursor
Which sanctuary sites of ALL are most resistant to therapy and common sites of relapse?
CNS and testes
What is the correct first step in diagnosis in a child with unexplained lymphadenopathy and cough?
What diagnosis should you consider in a teenager who presents with non tender cervical lymph node and high WBCs?
What cells would you expect to find on lymph node biopsy in a patient with Hodgkin lymphoma ?
What is the first course of action in a patient with fever who has had splenectomy?
What is the difference between lymphoblastic and nonlymphoblastic non Hodgkin lymphoma?
Lymphoblastic is t. Cell origin and non lymphoblastic is b. Cell origin
Where are the 3 most common sites of mass secondary to non Hodgkin lymphoma ?
Head, neck, abdomen
What 3 tumors should you consider in a child with non tender abdominal mass?
Non Hodgkin lymphoma
What is the difference in bone marrow findings between leukemia and lymphoma?
Leukemia has >25% blasts
Lymphomas has <25% blasts
How is langerhans cell histiocytosis diagnosed?
Skin biopsy and electron microscopy
How is langerhans cell histiocytosis treated ? (3)
Surgery, steroids or chemo
What diagnosis should you consider in a patient with a lytic skull lesion and seborrheic rash?
Langerhans cell histiocytosis
What urinary problems are associated with langerhans cell histiocytosis?
Diabetes insipidus and excessive urination
Where is the most common place for presentation of neuroblastoma?
What is the prognosis of neuroblastoma?
Survival 95% if occurs prior to 1 year - poor prognosis of older than 1
How is neuroblastoma diagnosed?
Tumor biopsy or high urine VMA/HMA plus bone marrow tumor
What is the best imaging study to find neuroblastoma?
CT with contrast
What are 3 common lab abnormalities associated with neuroblastoma ?
What is the most Likely cause of HTN in a patient with neuroblastoma?
Renal artery compression
What diagnosis should you consider in a patient with non tender abdominal mass, HTN and diarrhea ?