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Flashcards in Immunology Deck (27)
1

Name 3 important structural proteins found in the keratin layer and epidermis of skin

Filaggrin
Involucrin
Keratin

2

What is the alternative name for the keratin layer of skin?

Stratum corneum

3

Keratinocytes produce antimicrobial peptides (AMP) that can directly kill pathogens. True/False?

True
Act like antibiotics (non-cell-mediated immunity)

4

Can keratinocytes produce cytokines and chemokines?

Yes

5

Where are Langerhans cells located in the epidermis?

Prickle cell layer

6

Langerhans cells are the main skin immune cell. True/False?

True

7

How do Langerhans cells aid the immune response?

Produce liquid antigen/microbial fragments and present them to T-cells

8

What characterises Langerhans cells?

Birbeck granule

9

Healthy skin contains a large number of T-cells. The epidermis mainly contains CD4 T-cells. True/False?

False
Epidermis mainly contains CD8 cells

10

CD4 Th_ cells are associated with psoriasis
CD4 Th_ cells are associated with atopic dermatitis
CD4 Th_ cells are associated with psoriasis + atopic dermatitis

CD4 Th1 cells are associated with psoriasis
CD4 Th2 cells are associated with atopic dermatitis
CD4 Th17 cells are associated with psoriasis + atopic dermatitis

11

What is the function of TH1 cells?

Activate macrophages to destroy microorganisms

12

What is the function of TH2 cells?

Help B cells to make antibodies

13

What is the function of dermal dendritic cells?

Antigen presenting
Cyto/chemo -kine secretion

14

What is the function of plasmacytoid dendritic cells?

Produce IFN-alpha

15

MHC I present exogenous antigen to CD8 cells. True/False?

False
They present endogenous antigen to CD8 cells

16

MHC II present exogenous antigen to CD4 cells. True/False?

True

17

Psoraisis is triggered by environmental factors in genetically susceptible individuals. True/False?

True

18

Psoraisis lesions can be restored to normal state following effective therapy, even though there is chronic inflammation. True/False?

True

19

It is common for psoraisis plaques to become squamous cell carcinoma. True/False?

False

20

In psoraisis, the keratinocytes are stressed. Activated T-cells produce cytokines and IL-17A. What is the significance/function of IL-17A?

Stimulates keratinocyte proliferation, AMP release and neutrophilic killing
Basically acts as a synapsis between skin and immune system

21

People with atopic eczema always have dry skin. True/False?

True

22

Gene mutations for which protein are associated with severe/early atopic eczema?

Fillagrin

23

How does a broken down skin barrier cause eczema?

Exposed skin is sensitised to allergen and promotes colonisation by microorganisms

24

Allergic type 1 hypersentivity reactions typically occurs within minutes up to hours. What are the principle skin reactions that occur?

Urticaria
Angioedema

25

List step-up therapy for allergic reactions

Antihistamine
Prednisolone
Adrenaline

26

Allergic contact dermatitis is an example of which hypersensitivity reaction?

Type IV

27

What is the time period for type IV hypersensitivity reactions?

24-48hrs