Flashcards in PRECOCIOUS AND DELAYED PUBERTY Deck (21):
1
What is the definition of precocious puberty in females?
Sexual maturation takes place before the age of 8.
(9 in males)
2
What does the term thenarche mean?
First stage of breast development
3
What does the term adrenarche mean?
First stage of pubic hair development
4
What is the most common cause of precocious puberty in females?
Idiopathic in 74% of cases
5
What are the four organs/systems that may be affected where there is a non-idiopathic cause of precocious puberty?
CNS
Thyroid
Adrenals
Ovary
6
What are the CNS causes of precocious puberty?
Infection - meningitis, encephalitis, abscess
Tumours - gliomas, neurofibromas, ependymoma, hamartoma
Head trauma
Hydrocephaly
7
Does hyper or hypothyroidism cause precocious puberty?
Hypothyroidism
8
What are the adrenal causes of precocious puberty?
Congenital adrenal hyperplasia
Adrenal tumours
9
What are the ovary related causes of precocious puberty?
Oestrogen secreting tumours especially granulose cell tumours
Premature oestrogen secretion eg McCune-Albright syndrome
10
What is McCune-Albright syndrome?
A complex genetic disorder affecting the bone, skin, and endocrine systems that is associated with hyperfunctioning endocrine disease, fibrous dysplasia and café au lait macules.
11
What are the management options for someone with precocious puberty?
Endocrinologist referral - suppression of oestrogen and androgen production by GnRH analogues.
Psychological support
Surgical removal of tumour
12
What is the definition of delayed puberty in females?
No signs of secondary sexual development by the age of 13.
13
What is the most common cause of delayed puberty in females?
Gonadal failure
14
What are the categories of causes of delayed puberty?
Idiopathic
CNS
Thyroid
Adrenal
Ovary
Genetic
Chronic illness
15
What are the CNS causes of delayed puberty?
Infection - meningitis, encephalitis, abscess
Tumours - pituitary, destructive
Head trauma
16
Does hyper or hypothyroidism cause delayed puberty?
Hypothyroidism
17
What are the adrenal causes of delayed puberty?
Congenital adrenal hyperplasia
18
What are the ovary related causes of delayed puberty?
Gonadal failure
PCOS
Resistant ovary syndrome
19
What are the genetic diseases associated with delayed puberty?
Turner syndrome
Prader-Willi syndrome
Laurence-Moon-Biedl syndrome
Androgen insensitivity syndrome
Gonadal dysgenesis
Kalmann's syndrome
20
What chronic illnesses can lead to delayed puberty?
Anorexia nervosa
Diabetes mellitus
Renal disease
Cystic fibrosis
21