3. Multiple Myeloma Flashcards Preview

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Flashcards in 3. Multiple Myeloma Deck (32)
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1

Malignant proliferation of plasma cells that infiltrate bone marrow

Multiple Myeloma

2

Kahler’s disease aka

Multiple Myeloma

3

mc primary malignant bone tumor

Multiple Myeloma

4

- Anemia due to diseased hematopoietic tissue by
proliferating plasma cells
- Osteopenia in bones with red bone marrow
- Abnormal serum and urinary proteins
- Renal disease

Multiple Myeloma

5

cardinal symptom of Multiple Myeloma

Pain (aggravated by activity)

6

in multiple myeloma, slight strain may produce

pathologic
compression fractures that may result in
paraplegia

7

- Weight loss
- Cachexia
- Anemia
- Unexplained Osteoporosis

Multiple Myeloma

8

m/c affected bones in Multiple Myeloma

Spine and other red marrow containing bones such as flat bones

9

- “M spike” in 90% of patients
- IgG myeloma 50%
- Bence Jones proteinuria

Multiple Myeloma

10

For multiple myeloma we aspirate and biopsy bone marrow
of

sternum and ilium

11

reflects microscopic
appearance of nuclei in multiple myeloma

Round cell disorder

12

Multiple, permeative lesions, that are filled by gelatinous,
red, soft masses of neoplastic plasma cells, that are surrounded by areas of increased

osteoclastic activity

13

Multiple myeloma patients usually die of

pneumonia and
respiratory failure
(possibly renal failure)

14

May erode into adjacent bony structures and is m/c seen in nasopharynx

Extraosseous Plasmacytoma

15

are bones scans helpful for multiple myeloma?

NO

16

Bone scans will only show increased uptake in multiple myeloma if
__________ is present

pathological fracture

17

bone scan are negative in MM because they depend upon

osteoblastic
activity

18

Plasma cells release __________ , therefore osteoblasts are deficient in myeloma patients

osteoclastic activating
factor

19

Radiologic Hallmark of multiple myeloma

Punched Out Lesions

20

- Multiple round lytic lesions
- Raindrop skull
- Uniform lesions

Punched Out Lesions

21

may be earliest radiographic sign in Multiple Myeloma

Osteoporosis
(wrinkled vertebrae)

22

Pedicle sign is due to deficiency of

red marrow
(not a reliable sign for MM)

23

Osteoblastic lesions are very rare prior to

treatment with radiotherapy or drugs

24

over what % of patients with MM die within 3 years?

90

25

Agricultural workers, farmers, sheet metal workers and persons employed in the nuclear industry or
who are exposed to ________ are at increased risk
of developing ________.

wood dust, multiple myeloma

26

Patients with multiple myeloma commonly
present with

osteopenia and back pain

27

30% of MM patients present with a

pathologic fracture

28

Localized form of plasma cell proliferation

Solitary Plasmacytoma

29

Geographic radiolucent lesion, often highly
expansile, with a soap bubble appearance

Solitary Plasmacytoma

30

__ % of patients with a Solitary Plasmacytoma develop diffuse MM and die within 5 years

70