8. Skeletal Metastasis Flashcards Preview

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Flashcards in 8. Skeletal Metastasis Deck (58)
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1

almost all tumors have reported incidences of metastases to bone except tumors of

central nervous
system and basal cell carcinoma of the skin

2

Leptomeningeal Metastasis from primary Medulloblastoma of brain

Drop Metastasis

3

"sugar coating" enhancement

Drop Metastasis

4

4-year-old with medulloblastoma
presents with

morning vomiting and ataxia

5

responsible for ~70% of all bony metastases

Female breast cancer

6

results in ~60% of skeletal metastases

Prostate carcinoma

7

Metastatic osseous lesions in children <5 yo are usually due to

neuroblastoma

8

Metastatic Bone Tumors between 10-20 yo

Ewing’s and Osteosarcoma

9

Metastatic Bone Tumors Between 20 and 35 yo

Hodgkin’s lymphoma

10

May have increased serum calcium in

extensive lytic
metastasis

11

Blastic metastasis will increase

alkaline phosphatase

12

PSA and/or acid phosphatase will elevate if what is disrupted?

prostate
capsule

13

drop metastasis in CSF is an example of what type of mets?

Implantation or Seeding Metastasis

14

Valveless epidural vertebral veins that function as a venous lake or pool

Batson’s Venous Plexus

15

provides the
pathophysiological basis for early metastasis of
prostate cancer to pelvis, lumbar spine, and
remainder of axial skeleton

Prostatic venous plexus may drain directly into
vertebral venous plexus

16

Approximately 90% of patients present with Spinal metastasis present with

bone and/or back pain followed by radicular pain

17

most ominous symptom in patients with metastatic disease to the spine

Bone pain at night

18

Destruction due to osteoclast stimulating cytokines secreted by tumor cells.

Lytic Metastasis

19

Contrast is inserted into the thecal sac (subarachnoid space) via fluoroscopic
control

MYELOGRAPHY

20

Osteoid reacts to tumor cells by laying down nonneoplastic bone as a futile attempt at bone repair

Blastic Metastasis

21

Bone Scan will detect what percent of metabolic activity alteration?

3-5%

22

Radiation emitting substance, with low radiation dose a convenient half life for clinical use, is taken up and concentrated in
regions of high metabolic activity in bone

99mTc-MDP

23

bone scan with be positive how long before you see disease on plain film?

18 months

24

Useful for cortical bone involvement and presence of soft
tissue mass formation

Computed Tomography (CT, CAT):

25

Better than CT for detecting bone lesions and assessment of
soft tissue mass formation

MRI

26

Replacement of fatty bone marrow by tumor cells results in

loss of normal bright signal intensity on T1 weighted images

27

75% of metastatic bone tumors are

lytic

28

Motheaten or permeative pattern is classic in metastatic bone tumors and occurs mc with

breast and lung carcinoma metastasis

29

Primary tumors of thyroid and kidney may
produce

blow-out metastatic patterns

30

favors primary tumors

- Periosteal reactions
- Soft tissue mass
- Long lesions >6cm
- Most tumors that expand bone
- usually solitary, whereas metastatic lesions are usually multiple