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Flashcards in 4. Osteosarcoma Deck (55)
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1

Undifferentiated connective tissue and forms of neoplastic osteoid

Central Osteosarcoma

2

other types of osteosarcomas

• Multicentric
• Parosteal
• Secondary
• Extraosseous

3

Second m/c primary malignant bone tumor

Central Osteosarcoma

4

20% of all primary bone tumors, mostly in 10-25 year olds.

Central Osteosarcoma

5

Painful swelling at site of lesion (85%), with weight loss, fever, and cachexia

Central Osteosarcoma

6

May take ______ or longer to DX the central osteosarcoma tumor

6 months

7

Central osteosarcomas likes ____ bones,

long
(primarily knee and shoulder)

8

• 58% of Central osteosarcomas tumors occur around the ____.

knee
(Typically located in metaphysis)

9

m/c affected structure in spine from osteosarcoma

Vertebral body
(comp. Fx)

10

Secondary Osteosarcoma arise in Paget’s bone at __ %

44

11

If patient has Paget’s disease measure -__________ as a baseline study

alkaline
phosphatase

12

Will Alkaline Phosphatase
levels return to normal with removal of
tumor?

yes

13

__ % of Central osteosarcomas are neoplastic sclerotic bone, __ % are Purely lytic
and __ % are Mixed.

50, 25, 25

14

Pulmonary metastasis in osteosarcoma via hematogenous
route

Cannonball Metastases
(ossfified)

15

Cannonball metastases represents

sarcomatous pulmonary bone growths

16

Common subpleural nodules that have undergone
excavation --> rupture

Spontaneous Pneumothorax

17

Skeletal Metastasis may occur, called

Skip lesions

18

75% of Central Osteosarcomas are in

metaphyses of long bones

19

Central Osteosarcomas are m/c at the

distal end of femur
(and Proximal tibia and humerus)

20

what usually acts as barrier to spread?

Physis

21

- Focal lesion in metaphysis
- Mottled, permeative lesion
- Poorly defined zone of transition
- cortical distruption

Central Osteosarcoma

22

Dense ivory or sclerotic lesion filling medullary
space

Central Osteosarcoma

23

Spiculated or Sunburst periosteal reaction
in soft tissue and occasionally see Codman’s Triangles

Central Osteosarcoma

24

Ill-defined permeative mixed lytic/blastic lesion
(can cross the growth plate)

Osteosarcoma

25

soft tissue mass and spiculated periosteal reaction indicates

rapid growth

26

seen with large sclerotic
lesions

Cumulous cloud formation

27

Large soft tissue mass formation that may contain

ossification

28

Amputation if accessible and there is no...

(Radiotherapy for local pain control)

metastasis

29

Average time between recognition of pulmonary
disease and death is

6 months

30

Lytic presentation is rapidly

fatal