7. Hematologic Disorders Flashcards Preview

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Flashcards in 7. Hematologic Disorders Deck (36)
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1

Chronic, congenital, and hereditary hemolytic anemia almost exclusive in black individuals with episodic abdominal crises, jaundice, bone pain and dactylitis

Sickle Cell Anemia

2

Sickle Cell Anemia patients have a predisposition to

Salmonella osteomyelitis

3

Vascular compromise in sickle Cell Anemia results in

“H” or "fish" vertebra

4

Ischemia of the central endplate from

sickling crisis

5

bilateral hip pain showing bilateral
femoral head infarcts and osteonecrosis with subchondral collapse
of the superior femoral articular surface

Sickle Cell Anemia

6

Painful swellings of the hands and feet common in infancy, aggravated by cold weather.

Sickle Cell Dactylitis

7

Sickle Cell Dactylitis

Hand-Foot Syndrome

8

Individuals with sickle cell disease are predisposed
to _______ secondary to ischemic injury of both bone and GI tract

osteomyelitis

9

periostitis and osteopenia on radiograph

Osteomyelitis

10

The most sensitive study for sickle cell anemai is a

T1 fat saturation
study performed post gadolinium contrast

11

In SCA there will be ischemic changes to the ________ in
8-20% of patients

Femoral Head

12

Repeated episodes of splenic infarction causes the spleen to decrease in size

Autosplenectomy (from sickle cell)

13

Lytic processes are present at the metacarpals, along
with periostitis

Advanced Dactylitis from Sickle Cell Anemia

14

- H vertebra
- dactylitis
- splenomegaly
- hair on end
- osteonecrosis
- bone infarct
- osteomyelitis
- bone deformity
-

sickle cell anemia

15

Hereditary disorder of hemoglobin synthesis

Thalassemia
(Cooley’s anemia, Mediterranean anemia)

16

Retarded growth in thalassemia is due to

severe anemia

17

Hepatosplenomegaly in thalassemia is due to

severe hemolytic anemia

18

Mongoloid facies in thalassemia is due to

ineffective erythropoiesis and marrow hyperplasia

19

Maxillary overgrowth also called

rodent facies

20

- Expansion of medullary space
- Thinning of the cortices
- Expansion of bone diameter (Erlenmeyer Flask Deformity)
- Osteoporosis
- Resorption of fine trabeculae with thickening of the
remaining trabeculae
- Honeycomb trabeculae

Radiographic Findings of Thalassemia due to marrow hyperplasia

21

Erlenmeyer flask deformity and Premature fusion of growth plates

Thalassemia Growth Disturbances

22

In thalassemia the hyperplasia of bone
marrow results in

cortical thinning, loss of tubulation, and coarse trabeculae

23

Thalassemia
The radiating spicules of bone (“Hair-On-End) is due to

erythroid hyperplasia

24

Coarsened trabecular
pattern (honeycomb) and
Osteoporosis with
thinning of the cortices

Thalassemia

25

squaring of the
metacarpals

Thalassemia

26

Lobulated soft tissue
opacities are noted
overlying the ribs
anteriorly and
posteriorly

Extramedullary
Hematopoiesis in Thalassemia

27

two MC bleeding disorders with skeletal abnormalities which are both sex linked recessive

1. Classic Hemophilia (hemophilia A)
2. Christmas Disease (hemophilia B)

28

Females are carriers for Hemophilia gene but manifested
only in

males

29

Intraosseous Hemorrhage in Hemophilia leads to

hemophilic arthropathy

30

Hemophilic Arthropathy Resembles

Neurotrophic
Arthropathy (Charcot Joint)