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Flashcards in Anti-depressants Deck (29)
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1

what are 2 psychoses

schizophrenia
affective disorders

2

difference between schizophrenia and affective disorders

schizophrenia relates to issues with thought process but affective disorders to do with mood

3

2 affective disorders

mania and depression

4

emotional symptoms of depression

misery
low self esteem
loss of motivation
anhedonia- loss of ability to enjoy activities

5

biological symptoms fo depression

slowing of thought
loss of libido
loss of appetite

6

2 types of depression

unipolar-mood swings in same direction
bipolar- changing depression and mania

7

2 types of unipolar depression (depressive disorder)

Reactive depression- in response to life events
Endogenous depression- unrelated to external factors (is a familial pattern)

8

Features of depressive disorder

Late onset
Drug treatment for both types are the same

9

Features of bipolar depression

Early onset
Strong hereditary tendency
Treated with lithium

10

Monoamine theory of depression

Depression is a functional deficit of central MA
Mania is a functional excess of MA

11

2 chemicals associated with depression

Noradrenaline
5-HT

12

Speed of onset of anti depressant drugs

Delayed onset- potentially linked to adaptive changes in down regulation of a2, beta and 5HT receptors

13

3 main groups of antidepressant

Tricyclic antidepressant
Monoamine oxidase inhibitors
Selective serotonin receptor inhibitors

14

MOA of TCAs

Inhibit NA and 5 HT reuptake

15

Reason for delayed onset of TCAs

Delayed down regulation of beta-adrenoceptors and 5-HT2 receptors

16

Pharmacokinetics of TCAs

Rapid oral absorption
Hepatic metabolism to active metabolites
Highly plasma protein binding

17

Unwanted side effects at therapeutic dose

Atropine like effects
Sedation
Postural hypotension

18

Acute toxicity of TCAs

Delirium
Seizures
Ventricular fibrillation
Suicide attempts via OD

19

2 types of MAO

MAO-A= NA and 5-HT
MAO-B= Dopamine

20

MOA of MAOI

Inhibits monoamine oxidase to increase cytoplasmic NA nd 5 HT

21

Reason behind delayed effect of MAOi

Downregulation of 5-HT and NA receptors

22

Pharmacokinetics of MAOi

Rapid oral absorption
Metabolised in liver

23

Side effects of MAOis

Atropine like effects
Postural hypotension
Sedation
Weight gain
Hepatotoxicity

24

MOA of SSRIs

Inhibit 5 HT reuptake

25

Advantages of SSRIs

Less troublesome side effects
Safer in OD

26

Disadvantage of SSRIs

Less effective against severe depression

27

Pharmacokinetics of SSRISs

Delayed onset
Cant be administered with TCAs and MAOi

28

Unwanted effects of SSRIs

Nausea
Diarrorhoea
Insomnia
Loss of libido

29

What is the cheese reaction

Occurs in MAOi users who eat cheese. Drug interacts with tyramine causing an acute hypertension reaction