Anticonvulsants for Pharmacology and Therapeutics Flashcards Preview

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Flashcards in Anticonvulsants for Pharmacology and Therapeutics Deck (43)
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1

What is an epileptic seizure?

Manifestation of an abnormal or excessive synchronised discharge of a set of cerebral neurones

2

What are types of seizures

General
Partial

3

5 types of general seizure

Tonic-clonic
Tonic
Myoclonic
Status eplipticus
Absence

4

Features of tonic clonic seizures

Loss of conciousness
Muscle stiffening which leads to jerking
Deep sleep

5

What happens in absence features

Brief staring with behavioural arrest

6

What happens in tonic/atonic seizures

Sudden stiffening and loss of muscle control

7

What happens in myoclonic seizures

Sudden and brief muscle contractions

8

What happens in status epilepticus

Over 5 mins of continuous seizure

9

Types of partial seizures

Simple
Complex

10

What happens in simple partial seizure

Retained consciousness

11

What happens in complex partial seizure

Impaired consciousness

12

Difference between partial and general seizure

General simultaneously begins in both hemispheres of the brain whereas partial begins in particular area and may spread out

13

2 ways to diagnose epilepsy

EEG
MRI

14

Protein associated with docking of glutamate vesicle to presnaptic membrane

SVA2

15

2 most significant glutamate receptors

NMDA
Kainate

16

What state is VGSC in before it fully depolarises

Inactive

17

Pharmacodynamics of carbamazepine

Stabilises inactive state of Na+ channel

18

Pharmacokinetics of carbamazepine

Enzyme inducer
Onset of activity is 1 hour
16-30hr half life

19

Issue of carbamazepine

Severe skin side effects if have HLA-B-1502 allele

20

Pharmacodynamics of lamotrigine

Inactivates Na+ channels

21

Pharmacokinetics of lamotrigine

Onset activity of 1 hour
24-34 hr half life

22

What is lamotrigine used for

Tonic clonic and ascence seizures

23

What is carbamazepine used for

Tonic clonic and partial seizures

24

Pharmacodynamics of ethosuximide

T-type Ca channel antagonist

25

Where is MOA of ethosuximide

Relay thalamic neurones

26

Pharmacokinetics of ethosuximide

50hr half life

27

What is ethosuximide used for

Abscence seizures

28

Pharmacodynamics of levetiracetam

Binds to SVA2 protein

29

Pharmacokinetics of levetiracetam

1 hour onset
half life 10hrs

30

Use for levetiracetam

Myoclonic seizures