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antimykotika Flashcards

(5 cards)

1
Q

polyener

A
  • ergosterolsyntes hämmas
  • vattenkanaler bildas
  • ökad membranpermabilitet
  • celldöd
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2
Q

Triazoler

A
  • integration med cytokrom P450

- ger brist på ergosterol och ansamling av toxiska steroler i cellmembranet

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3
Q

Echinocandiner

A
  • hämning av syntesen av beta-1,3-D-glykan
  • brist på cellvägsglukan
  • osmotiskt instabilitet, lys, celldöd
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4
Q

nukleosidanaloger

A

interferens med RNA syntes

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5
Q

vilka typer av resistens finns?

A
  • artrelaterad, naturlig

- förvärvad resistens efter intermittent behandling, oftast innefattande efflux av LM

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