- ergosterolsyntes hämmas - vattenkanaler bildas - ökad membranpermabilitet - celldöd

- integration med cytokrom P450 - ger brist på ergosterol och ansamling av toxiska steroler i cellmembranet

- hämning av syntesen av beta-1,3-D-glykan - brist på cellvägsglukan - osmotiskt instabilitet, lys, celldöd

antimykotika Flashcards by Evelina Ohlson

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polyener

ergosterolsyntes hämmas
vattenkanaler bildas
ökad membranpermabilitet
celldöd

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Triazoler

integration med cytokrom P450

- ger brist på ergosterol och ansamling av toxiska steroler i cellmembranet

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Echinocandiner

hämning av syntesen av beta-1,3-D-glykan
brist på cellvägsglukan
osmotiskt instabilitet, lys, celldöd

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nukleosidanaloger

interferens med RNA syntes

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vilka typer av resistens finns?

artrelaterad, naturlig

- förvärvad resistens efter intermittent behandling, oftast innefattande efflux av LM

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antimykotika Flashcards

(5 cards)