Chapter 14 - RBC CIS Flashcards Preview

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Flashcards in Chapter 14 - RBC CIS Deck (38):
1

Low MCV and high RDW is ___ anemia until proven otherwise

iron deficiency anemia (chronic blood loss anemia)

2

Chronic Blood Loss Anemia is most likely due to

colonic carcinoma

3

Normal RCW (red cell distribution width)

11.5-14.5

4

Normal Hgb

about 15

5

Normal Hct

about 45

6

normal platelet count

150,000 - 450,000

7

Ferritin is 10ug/L. Ferritin deficiency causes what? Why?

Chronic blood loss over time causes ferritin deficiency. Ferritin is for iron storage

8

Define Pica

People with (iron deficiency) anemia who eat anything – especially dirt or ice.

9

Normal MCV. What's above/below?

80-100
Above=megaloblastic
Below = microcytic

10

Any disorder of ineffective erythropoiesis that starts as normocytic, can COT to what?

Microcytic

11

Normal MCHC

31-37%

12

Oral iron supplementation given to a person with chronic blood loss anemia prior to surgery for colon carcinoma. Reticulocytosis on PS noted in about one week. Why?

Person had IDA - pt is receiving oral iron and the marrow responds with reticulocytes (RDW will probably increase even more).

13

Will ACD repsond to Fe?

Probably not.

14

What type of anemia is asosciated with membrane defect?

extravascular hemolytic anemia.

15

RF+ and erosive, inflammatory arthritis of hands and elbow. WBC elevated, left shift, thrombocytosis. Hgb is 12 (so Hct is ~36) RBC has normocytic, normochromic anemia. What is this?

Anemia of Chronic Disease

16

Episodic manifestations of hemolysis. Acutely ill with severe anmeia. Precipitated bu infeciton or drugs

G6PD deficiency

17

High serum ferritin seen in

ACD

18

Significant thrombocytopenia, PS shows leukoerythroblastosis. Marrow transplant 10 year ago during radiation for papillary carcinoma of the thyroid. Presents with normocytic, normochromic anemia.

MDS or MPD

19

Parkinson-like neuro symptoms. Moderate leukopenia with MCV of 110 (high) and PS multiple hypersegmented PMNs (means megaloblastic). Labs indicate elevated homocysteine and methymalonate. Most likely?

Pernicious Anemia

20

Hypersegmented PMNs means

megaloblastic

21

Labs for homocysteine and methymalonate. in folate deficiency.

Elevated homocyteine, but not methymalonate.

22

24 year old woman with lethargy and low libido. Basophilic stippling is identified in some erythrocytes. Serum ferritin increased significantly. HbA2 is 7% (elevated) and small quantity of HbF detected upon electrophoresis. Most likely?

Beta-thalassemia minor (younger in life)

23

HbF in beta-thalassemia major v. minor

increased in major, not much in minor.

24

excess of beta globin chains form Beta 4 tetramers known, seen in newborns.
excess gamma chains form gamma 4 tetramers - this is?

HbH = severe microcytic anemia

Hydrops fetalis, Hemoglobin barts = death

25

Immunohemolytic anemia:
IgM antibody

Cold agglutinin(i.e. mono or mycoplasma infection)

26

Warm antibody associated with...

SLE, diret coombs IGG

27

Most common hematologic manifestation of HIV

thrombocytopenia

28

1. A 37 year old white female. 12gm/dl Hgb, MCV of 75fl and RDW of 16. Plts 30,000. Sparse petechiae, weak, pale pallor, pale conjuctivae, ferritin low. Most likely which of the following?

Primary Chronic ITP

29

Modestly increased marrow megakaryocytes. PS has abnormally large platelets.

TTP

30

Target cells and spherocytes

Thalassemias

31

Haptoglobin decrease indicates

Hemolytic anemia (both intravascualr or extravascular)

32

6 year old male hx of easy bruising with casual physical contact. PT normal, PTT elevated. What is most likely?

Hemophilia A and B

33

IDA v. ACD levels:
- Free iron
- Transferrin saturation
- TIBC
- Serum ferritin
- Hepcidin

- Free iron - low, low
- Transferrin saturation - low, high
- TIBC - high, low
- Serum ferritin - low, high
- Hepcidin - low, high

34

Low plt count, PTT/PT prolonged, fibrin split products identified, microangiopathic fragmented red cell forms.

DIC

35

low MCV, low Hct/Hg. IDA. PBS=

hypochromasia

36

nucleated RBC suggest?

hemolysis or a disease infiltrating and replacing bone marrow (hymolysis=hyperBr)

37

anisocytosis and poikilocytosis

alpha thalasemia

38

high HCt v low Hct

high = polycythemia
low = anemia