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Flashcards in WBC Genetics Deck (47)
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1

t(12;21) involving RUNX1 and ETV6

B-ALL

2

NOTCH1 mutations

T-ALL and CLL(worse prognosis)

3

90% of ALLs have what numerical or structural change?

hyperploidy

4

TdT+

pre-lymphoblasts (B or T)

5

CD19

pre-B lymphoblast (B-ALL)

6

t(9;22) - what gene is changed and what two neoplasms result respective prognosis

Philadelphia chromosome = BCR-ABL tyrosine kinase activation (B-ALL=worse prognosis and CML=better prognosis)

7

Deletions of 13q14.3, 11q, 17p, and trisomy 12q

CLL/SLL

8

CD19, CD20, CD23, CD5

CLL/SLL

9

t(14;18) leading to overexpression of BCL2-IgH, which antagonizes apoptosis and promotes survival of this tumor cell (90%)

Follicular Lymphoma

10

MLL2 gene (90%)

Follicular Lymphoma

11

CD19, CD20, surface Ig, BCL6+, BCL2-

Follicular Lymphoma

12

BCL6+ is normal or pathologic in LN follicles?
BCL2+ is normal or pathologic in LN follicles?
Where do you assay these?

normal
pathologic

Assay them in the lymph nodes, not the peripheral blood.

13

BCL6+ (30%), t(14;18)=BCL2 (10%), MYC gene (5%)

Diffuse Large B-Cell Lymphoma

14

CD19, 20, 10, BCL6+, surface Ig

Diffuse Large B-Cell Lymphoma

15

t(8;14) = c-myc+ (all have this)

Burkitt Lymphoma

16

EBV

-Burkitt (25%)
-Immunodeficiency-associated large B-cell lymphoma
-Extranodal NK-T-cell Lymphoma
-Hodgkin Lymphoma

17

CD19, 20, 10, BCL6+, BCL2-

Burkitt

18

diverse rearrangements involving IgH, 13q deletions
Cyclin D1

Multiple myeloma

19

IgG-Kappa combination (IgG present in 55%)

Multiple myeloma

20

CD138 (aka syndecan-1)

Plasma cell tumors (Multiple myeloma)

21

MYD88 gene

Lymphoplasmacytic lymphoma

22

t(11;14) creating overexpresion of cyclinD1-IgH fusion gene

Mantle Cell Lymphoma

23

CD19, 20, Ig
CD5+
CD21-

Mantle Cell Lymphoma

24

t(11;18) t(1;14) t14;18) creating MALT-1IAP2, BCL10-IgH, and MALT1-IgHfusion genes

Marginal Zone Lymphoma

25

activating point mutations in serine/threonine kinase BRAF

Hairy Cell Leukemia

26

CD19, 20
**CD11c**, CD25, CD103, annexin A1

Hairy Cell Leukemia

27

Rearrangements of ALK gene on ch2p23 (children) and prognosis

Anaplastic Large Cell Lymphoma - good prognosis

28

Prognosis for ALK- tumors that are morphologically similar to Anaplastic Large Cell Lymphoma (adults)

poor prognosis

29

CD30+, ALK+

Anaplastic Large Cell Lymphoma

30

HTLV-1 provirus present in tumor cells (CD4+ T cells)

Adult T-Cell Leukemia/Lymphoma