Fitz - Managing Complications Flashcards Preview

Hematology and Oncology > Fitz - Managing Complications > Flashcards

Flashcards in Fitz - Managing Complications Deck (15):
1

HL regimen

ABVD - Doxorubicin, Bleomycin, Vinblastine, Dacarbazine

2

Type of activity in the ABVD regimen

Doxorubicin - Intercalating Agent
Bleomycin - antibiotic
Vinblastine - Antimitotic, destabilizer of microtubules
Dacarbazine - alkylating

3

Type of clearance in the ABVD regimen

Doxorubicin - hepatic
Bleomycin - renal
Vinblastine - CYP3A4/5
Dacarbazine - hepatic

4

Toxicity of ABVD regimen

Doxorubicin - cardiomyopathy
Bleomycin - pulmonary fibrosis
Vinblastine - neuropathy
Dacarbazine - marrow suppression

5

NHL regimen

CHOP -
Cyclophosphamide
Doxorubicin
Vincristine
Prednisone

6

NHL regimen activity

Cyclophosphamide - alkylating (N mustard)
Doxorubicin - intercalating
Vincristine - antimitotic, destabilizer of microtubules
Prednisone - CS

7

NHL Clearance

Cyclophosphamide - CYP3A4/5; CYP2D6 prodrug
Doxorubicin - hepatic
Vincristine - CYP3A4/5
Prednisone - 100% bioavailable

8

NHL toxicity

Cyclophosphamide - acrolein (hemorrhagic cystitis)
Doxorubicin - Cardiomyopathy
Vincristine - neuropathy, constipation
Prendisone - hyperglycemia/osteopenia

9

Antiemetic classes best used for acute cytotoxic emesis

1. 5HT3 receptor antagonists (~setron --> vagal afferent and area postrema)
2. D-2 R antagonist - METOCLOPRAMIDE

10

Antiemetic classes best used for delayed cytotoxic emesis - caused by what drug?

1. NK1 R antagonists (in vagal afferent and area postrema) - APREPITANT
Caused by cisplatin

11

dronabinol

Cannabinoid receptor agonist - used if refractory to other agents

12

leucovorin used for what?

with HDMTX, to replenish folate pool in normal cells - bypasses DHFR

13

MESNA used for what? Give when?

hemorrhagic cystitis caused by acrolein (cyclophosphamide/CHOP or Ifosfamide).

Give prophylactically.

14

Amifostine used for what?

Nephrotoxicity associated with cisplatin.

15

Five of the worse CINV drugs

1. CARmustine (nitrosourea)
2. DACARbazine (alkylating agent)
3. MECHlorethamine (nitrogen mustard)
4. CYCLophophamide (nitrogen mustard)
5. Cisplatin