Hubbard - WBC Flashcards Preview

Hematology and Oncology > Hubbard - WBC > Flashcards

Flashcards in Hubbard - WBC Deck (16)
Loading flashcards...
1
Q

ATRA is used for?

Methotrexate used for

A

Maintenance of AML only

Maintenance of ALL

2
Q

Ommaya reservoir is adventageous when/how?

A

For leptomeningeal disease, when chemo does not pass through the BBB into the CSF. Better than lumbar puncture.
-Catheter inserted into lateral ventricle for intrathecal therapy.

3
Q

Symptoms of leukemic meningitis

A

N/HA due to leptomeningeal infiltration. Use Ommaya reservoir.

4
Q

For AML, when do you give antibiotics for feveR?

A

Even if the cause is not found, give broad spectrum.

5
Q

G-CSF and CM-CSF given for what?

A

after completion of AML chemo (ATRA?), shortens period of severe myelosuppression.

6
Q

Leukostasis in CML - s/s; cause, appears during what phases?

A
  • Dyspnea, drwsiness, loss of coordination, confusion
  • Caused by leukocyte sludging into pulmonary (lungs)/cerebral vessels.
  • Appears during accelerated and blastic phase of CML.
7
Q

Dx of CML

A
  • Anemia + SM in 30-50%; LUQ fullness and early satiety.

- Leukocytosis with low LAP. Hypercellular bone marrow with myeloid hyperplasia.

8
Q

Cytogenetics of CML.

A

t(9;22)

9
Q

When is imatinib used in CML? What type of drug is this?

A

To decrease development of accelerated or blastic phase.

It is a TKI, first line therapy.

10
Q

Middle aged white man, + pancytopenia + SM +nonaspirable marrow

A

HCL

TRAP

11
Q

Treatment of HCL

A
  1. Mild cytopenia, no infection hx, marrow infiltration low = NO THERAPY
  2. First line = ADI
  3. Relapses = rituximab
12
Q

Rai staging

A

0 = excellent prognosis

3, 4 = anemia an dthrombocytopenia, worse prognosis (have Hb

13
Q

Clinical manifestations of NHL

A

Lymphadenopathy +/- compression related presentations (i.e. SVC sydnrome w/distended superficial veins)
-firm and NT

14
Q

Dx of lymphoma - use what (2)

Staging of lymphoma - use what (1)

A
  • Fine needle aspirate - DO NOT USE
  • Excisional Biopsy (preferred for initial diagnosis) –> use Core Needle Biopsy for primary diagnosis (if pt has heart condition/cannot be put under anesthesia)
  • CT imaging
15
Q

Burkitt requires what in addition to tx?

A

CNS prophylaxis + intrathecal chemo or high-dose methotrexate

16
Q

LN pain with alcohol/beer consumption

A

HL