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Flashcards in Hubbard - WBC Deck (16):
1

ATRA is used for?
Methotrexate used for

Maintenance of AML only
Maintenance of ALL

2

Ommaya reservoir is adventageous when/how?

For leptomeningeal disease, when chemo does not pass through the BBB into the CSF. Better than lumbar puncture.
-Catheter inserted into lateral ventricle for intrathecal therapy.

3

Symptoms of leukemic meningitis

N/HA due to leptomeningeal infiltration. Use Ommaya reservoir.

4

For AML, when do you give antibiotics for feveR?

Even if the cause is not found, give broad spectrum.

5

G-CSF and CM-CSF given for what?

after completion of AML chemo (ATRA?), shortens period of severe myelosuppression.

6

Leukostasis in CML - s/s; cause, appears during what phases?

-Dyspnea, drwsiness, loss of coordination, confusion
-Caused by leukocyte sludging into pulmonary (lungs)/cerebral vessels.
-Appears during accelerated and blastic phase of CML.

7

Dx of CML

-Anemia + SM in 30-50%; LUQ fullness and early satiety.
-Leukocytosis with low LAP. Hypercellular bone marrow with myeloid hyperplasia.

8

Cytogenetics of CML.

t(9;22)

9

When is imatinib used in CML? What type of drug is this?

To decrease development of accelerated or blastic phase.

It is a TKI, first line therapy.

10

Middle aged white man, + pancytopenia + SM +nonaspirable marrow

HCL
TRAP

11

Treatment of HCL

1. Mild cytopenia, no infection hx, marrow infiltration low = NO THERAPY
2. First line = ADI
3. Relapses = rituximab

12

Rai staging

0 = excellent prognosis
3, 4 = anemia an dthrombocytopenia, worse prognosis (have Hb

13

Clinical manifestations of NHL

Lymphadenopathy +/- compression related presentations (i.e. SVC sydnrome w/distended superficial veins)
-firm and NT

14

Dx of lymphoma - use what (2)
Staging of lymphoma - use what (1)

-Fine needle aspirate - DO NOT USE
-Excisional Biopsy (preferred for initial diagnosis) --> use Core Needle Biopsy for primary diagnosis (if pt has heart condition/cannot be put under anesthesia)
-CT imaging

15

Burkitt requires what in addition to tx?

CNS prophylaxis + intrathecal chemo or high-dose methotrexate

16

LN pain with alcohol/beer consumption

HL