Flashcards in Copper Deck (14)
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1
what are the 2 valence states of copper
1. Cuprous (Cu+)
2. Cupric (Cu2+)
2
what three ways does copper become absorbed on brush border
1. copper transporter (Ctr1)
2. DMT1 - symports Cu+ and H+ simultaneously
3. amino acids transports - for cysteine and histidine
3
copper ions damage cells through
fenton reaction
4
copper found in body's cells bound to
1. glutathione
2. metallothionein
3. chaperone proteins
5
____ is used for Cu+ transport
Atox1
6
_____ is for SOD synthesis
CCS (copper chaperone for superoxide dismutase)
7
copper is transported in the blood to the liver via
1. albumin
2. transcuprein
8
what organ is the main storage site for copper
liver (bound to metallothionein)
9
what are the 8 metalloenzymes of copper
1. ceruloplasmin
2. cytochrome C oxidase
3. superoxide dismutase
4. hephaestin
5. dopamine hydroxylase
6. tyrosinase
7. peptidyglycine alpha-amidating monoxygenase
8. lysyl oxidase
10
what produces melanin
tyrosinase
11
deficiency in tyrosinase leads to
albinism
12
defective biliary copper excretion is the result of
wilson's disease
13
ATP7B is also called
Wilson's ATPase
14
