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Nutritional Biochem > Copper > Flashcards

Flashcards in Copper Deck (14)
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1

what are the 2 valence states of copper

1. Cuprous (Cu+)
2. Cupric (Cu2+)

2

what three ways does copper become absorbed on brush border

1. copper transporter (Ctr1)
2. DMT1 - symports Cu+ and H+ simultaneously
3. amino acids transports - for cysteine and histidine

3

copper ions damage cells through

fenton reaction

4

copper found in body's cells bound to

1. glutathione
2. metallothionein
3. chaperone proteins

5

____ is used for Cu+ transport

Atox1

6

_____ is for SOD synthesis

CCS (copper chaperone for superoxide dismutase)

7

copper is transported in the blood to the liver via

1. albumin
2. transcuprein

8

what organ is the main storage site for copper

liver (bound to metallothionein)

9

what are the 8 metalloenzymes of copper

1. ceruloplasmin
2. cytochrome C oxidase
3. superoxide dismutase
4. hephaestin
5. dopamine hydroxylase
6. tyrosinase
7. peptidyglycine alpha-amidating monoxygenase
8. lysyl oxidase

10

what produces melanin

tyrosinase

11

deficiency in tyrosinase leads to

albinism

12

defective biliary copper excretion is the result of

wilson's disease

13

ATP7B is also called

Wilson's ATPase

14

genetic disorder characterized by

copper toxicity